The paper discusses modern approaches to the assessment of etiopathogenesis and treatment of chronic pharyngitis. The results of the application of a new diagnostic method, mass spectrometry of microbial markers, which makes it possible to detect microorganisms in a biofilm in a "dormant state" under the protection of mucin, are presented. Using this express method, it is possible to determine the content of 57 microorganisms in a pharyngeal smear 2 hours after delivery of the biomaterial to the laboratory. Using mass spectrometry of microbial markers, it was found that 91% of people with chronic pharyngitis (n= 62) had an increased total content of microorganisms, which indicates the need for antibacterial therapy; 87% of patients had increased endotoxin levels, which is a sign of general intoxication; 71% of patients had reduced plasmalogen levels and these patients They may be at increased risk for lipid metabolism disorders.; in 100% of the examined patients with frequent exacerbations of chronic pharyngitis, the nasopharyngeal microflora (coccoid) is detected in the pharynx, as well as new etiopathogenetically significant microorganisms (undetectable by PCR and crops), among which 7 are transient (their level is normally 0 in the pharynx), 11 are resident (6 occur in the pharynx in the norm is at a minimum level and 5 is at a high level). 

chronic pharyngitis, mass spectrometry, immunity, dysbiosis, pathogenesis, laboratory diagnostics, antibacterial drugs.

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