The diagnostic challenges, clinical features, treatment options, and prevention strategies for acute viral hepatitis with parenteral transmission mechanisms (specifically hepatitis D and G), which comprise a small proportion of all acute viral hepatitis cases, are discussed in this study. The widespread occurrence of these infections, combined with advancements in modern diagnostic techniques and the high frequency of progression to chronic forms, underscores the significance of addressing viral hepatitis as a critical issue for public health, particularly within the context of domestic healthcare systems.

The article provides an overview of the importance of serological markers for hepatitis D and G viruses, presenting an analysis of their clinical interpretation. In-depth discussions on modern pharmacological treatments, including interferon-based therapies, are included. Additionally, the necessity for specific preventive measures, post-exposure prophylaxis, and passive immunization strategies are thoroughly considered.

In some instances, subclinical infections may progress to rapidly advancing chronic liver diseases, eventually leading to cirrhosis or hepatocellular carcinoma. Following an incubation period of variable length, viral replication within liver cells reaches its peak, resulting in the presence of viral components in bodily fluids and excreta. This process induces hepatocyte necrosis and triggers an inflammatory response, clinically manifesting as liver damage, accompanied by corresponding laboratory abnormalities. The host's immunological response plays a pivotal, albeit not fully understood, role in the pathogenesis of the disease.

Acute viral hepatitis with parenteral transmission ranks among the most significant infectious diseases in Uzbekistan, primarily due to its high prevalence, severe clinical course, and frequent progression to chronic forms. Addressing this urgent public health concern is intrinsically tied to advancements in the diagnosis, prevention, and treatment of acute viral hepatitis.

a hepatites B, C, D, G; a virus of a hepatites B, C, D, G; methods diagnostics, clinic, drug treatment,preventive maintenance.

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