Organic carbamates play a crucial role in modern medicinal chemistry due to their stability, bioavailability, and functional versatility. This review explores their chemical properties, synthetic methodologies, and pharmacological applications. The analysis highlights their significance in protease inhibitors, neuroactive drugs, prodrugs, and anthelmintic agents. Advances in sustainable synthesis, particularly CO₂-based carbonylation, enhance their applicability while addressing environmental concerns. Despite their advantages, hydrolytic instability remains a challenge, necessitating further research for improved structural modifications. Future advancements in carbamate-based therapeutics will drive innovation in drug design and development.

Organic carbamates, drug design, medicinal chemistry, enzyme inhibitors, prodrugs, synthetic methodologies, pharmacokinetics.

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