Articles | Open Access | https://doi.org/10.55640/

THE IMPORTANCE OF DETERMINING THE STATUS OF VASCULAR ENDOTHELIUM IN THE DEVELOPMENT OF GLOMERULARY AND TUBULOINTERSTITIAL FIBROSIS

Shukurova Umida Pulatovna,Umarova Nargiza Nuritdinovna , 1.PhD, Head of the Educational and Methodological Department of EMU UNIVERSITY, 2.Republican Emergency Medical Aid Scientific Center Ultrasound examination doctor

Abstract

The article presents the results of a study to determine the prognostic significance of markers for predicting the degree of damage to renal structures at the stages of treatment of patients with nephrosclerosis on the background of chronic pyelonephritis.

Keywords

Endothelial dysfunction, apoptosis, endothelin-1, plasminogen activator inhibitor - PAI-1, von Willebrand factor, fibrinolysis, endothelial cell desquamation, hypercoagulation.

References

Smirnov A. V., Sergeyeva T. V. et al. Endothelial dysfunction and apoptosis in the early stages of chronic kidney disease // Therapeutic archive – 2018. –T.84, №6. –P.9-15.

Danchenko YE.O. Laboratory methods for assessing apoptosis and necrosis. 2019. –P.18-19.

Bobkova I.N., Kozlovskaya L.V., Rameyeva A.S. Clinical significance of detecting markers of endothelial dysfunction and angiogenesis factors in urine in the assessment of tubulointerstitial fibrosis in chronic glomerulonephritis. Therapeutic archive, 2017. – №6. –P.10-15.

Margiyeva T.V., Sergeyeva T.V., Golovchenko Y.I., Treshinskaya M.A. Review of modern presentations on endothelial dysfunction / P.L. Shupika, National Medical Academy. Kiev, 2018. –№1. – P.38-39.

Shukurova U.P., Mukhamedova N.Kh. Identification of early diagnostic markers of renal nephrosclerosis in chronic pyelonephritis. Monograph. Tashkent-2024. –P. 60-71

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THE IMPORTANCE OF DETERMINING THE STATUS OF VASCULAR ENDOTHELIUM IN THE DEVELOPMENT OF GLOMERULARY AND TUBULOINTERSTITIAL FIBROSIS. (2025). International Journal of Medical Sciences, 5(04), 139-142. https://doi.org/10.55640/