Ulcerative colitis (UC) is a chronic inflammatory bowel disease that primarily affects the colon and rectum, but it is also associated with extra-intestinal manifestations, including renal dysfunction. The kidneys in experimental UC models, particularly those induced by dextran sulfate sodium (DSS) or trinitrobenzene sulfonic acid (TNBS), exhibit several morphological and morphometric changes. These include inflammation, edema, glomerular damage, interstitial fibrosis, and altered renal blood flow, which can lead to impaired kidney function. The pathophysiological mechanisms behind renal involvement in UC are multifactorial, with systemic inflammation, oxidative stress, and ischemia playing key roles. The article provides a comprehensive review of the morphological and morphometric alterations in the kidneys observed in experimental UC models, discusses the potential underlying mechanisms, and highlights therapeutic interventions aimed at mitigating kidney damage. A better understanding of these changes is crucial for developing strategies to prevent renal complications in patients with UC.

ulcerative colitis (UC), renal changes, experimental models, morphological alterations. morphometric changes, inflammation, kidney fibrosis, glomerular damage, oxidative stress, renal dysfunction, therapeutic interventions, systemic inflammation, kidney pathology

: Ulcerative Colitis: Diagnosis and Treatment - AAFP

: Ulcerative colitis | Nature Reviews Disease Primers

: Identification of shared gene signatures and molecular mechanisms ...

: Dual role of melatonin as an anti-colitis and anti-extra intestinal ...

: Insights into renal and urological complications of inflammatory ...

: Ulcerative Colitis Guidelines - Medscape Reference

: Advances in cross-sectional imaging in inflammatory bowel disease

: Innovative Animal Model of DSS-Induced Ulcerative Colitis in ... - MDPI

: An Antibiotic-Responsive Mouse Model of Fulminant Ulcerative Colitis

: Acute Kidney Injury in the Context of Inflammatory Bowel Disease

: Nephrotic syndrome in ulcerative colitis - PubMed

: Different renal manifestations associated with very early onset ...

: Inflammatory bowel disease increases the levels of albuminuria and ...

: Naringin Exerts Therapeutic Effects on Mice Colitis - Frontiers

: Kidney Manifestations of Inflammatory Bowel Diseases

: kidney, ulcerative colitis, morphology - INOVATUS JOURNALS

: Change in Renal Glomerular Collagens and Glomerular Filtration ...