Angular cheilitis (AC) is a clinical disorder characterized by erythema, cracks, ulcerations, and crusting at one or both corners of the mouth, beginning at the mucocutaneous junction and extending to the skin surface. The etiology of AC is quite diverse and difficult to determine, since it is considered a multifactorial disease of infectious origin. The development of this pathology is based on both systemic and local factors, requiring a multidisciplinary approach, since this disease shows a high percentage of relapses. Among the systemic factors leading to the development of angular cheilitis, the main role is played by nutritional deficiency, namely iron and B vitamins (riboflavin, pyridoxine, cobalamin, and niacin). When considering the local etiology, any factor that creates a chronic and moist environment for microbial growth at the corners of the mouth may be responsible for the etiology of AC, such as habitual lip licking, thumb sucking, biting the corners of the mouth, etc. Investigation of the exact etiology of the development of AC is crucial to provide effective, successful comprehensive treatment to relieve the patient's discomfort and pain.

angular cheilitis; angular cheilitis; multifactorial disease; B vitamins; anemia.

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