Articles | Open Access | https://doi.org/10.55640/

PHYSIOLOGY AND CLINICAL SIGNIFICANCE OF THE SOMATOTROPIC HORMONE

Musliman Abdulvosidovna Madaminjonova,Nabijon Alijonovich Razzakov , Kokand University Andijan branch

Abstract

The somatotropic hormone (STH), or growth hormone, is one of the key peptide hormones that regulates growth and metabolic processes in the human body. This article provides an in-depth analysis of the biosynthesis, secretion mechanisms, physiological effects, clinical significance, and pathological conditions associated with STH. Disorders such as gigantism, acromegaly, and pituitary dwarfism, as well as diagnostic and treatment methods, are reviewed on a scientific basis. The article also highlights the role and prospects of STH in modern clinical medicine.

Keywords

Somatotropin, growth hormone, gigantism, acromegaly, dwarfism, insulin-like growth factor (IGF-1)

References

Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams Textbook of Endocrinology. 14th ed. Philadelphia: Elsevier; 2022.

Molitch ME. Diagnosis and Treatment of Growth Hormone Deficiency in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2017;102(3):1001-1007. doi:10.1210/jc.2016-2568

Ho KK, Participants of the GH Deficiency Consensus Workshop. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: A statement of the GH Research Society in association with the European Society of Endocrinology, the Lawson Wilkins Pediatric Endocrine Society, and The Endocrine Society. Eur J Endocrinol. 2007;157(6):695-700.

Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW, Weil PA. Harper’s Illustrated Biochemistry. 31st ed. New York: McGraw Hill Education; 2018.

Vilar L, Vilar CF, Lyra R, Naves LA. Acromegaly: Clinical features, diagnostic tools, and therapeutic approaches. J Endocrinol Invest. 2017;40(3):277-293. doi:10.1007/s40618-016-0562-9

Devesa J, Tresguerres JAF. Growth hormone and the regulation of physiological functions in the body. J Endocrinol Metab. 2019;9(3):77-87.

Rosenfeld RG, Cohen P. Disorders of growth hormone/insulin-like growth factor secretion and action. In: Melmed S, editor. The Pituitary. 2nd ed. Philadelphia: Elsevier; 2006. p. 437-502.

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PHYSIOLOGY AND CLINICAL SIGNIFICANCE OF THE SOMATOTROPIC HORMONE. (2025). International Journal of Medical Sciences, 5(05), 192-196. https://doi.org/10.55640/