Background: According to some studies, patients with obesity seem to be more prone to have severe COVID-19 symptoms, than non-obese people. The association between obesity and an increased risk of hospitalization, critical conditions, or even death as a result of COVID-19 in Uzbekistan is currently under research. The aim of the study was to evaluate the impact of obesity on the severity and course of disease of COVID-19.

Design and methods: The design of the study is an observational cohort study. The patients were followed over 30 days, after COVID-19 disease to examine short-term outcomes. Among patients seeking medical treatment or receiving the initial medical communication in distribution centers in Tashkent, Uzbekistan, we selected 4675 consecutive patients, who had proven SARS-CoV-2 PCR-positive test results. By using a t-test to continuous data related with an increased risk of hospitalization, critical conditions, or even mortality owing to COVID-19 in Uzbekistan, we compared individuals with obesity and those who did not have obesity. Furthermore, we chose to evaluate data from databases like as PubMED, Elsevier, Cochrane, Lancet, World Obesity, Science, and World Health Organization guidelines through to the end of the еar 2021, as well as data from existing databases. In addition, we investigated a number of scientific online sites, including karger.com, Medscape, CDC.gov, and Google scholar to find the association between COVID-19 and obesity.

Obesity, Covid-19, Risk factor, Mechanism.

Barrera, E.L. (2018) Hunger and obesity: The "double burden" of malnutrition in a simple framework, Hunger and Obesity: the "double burden" of malnutr... Available at: https://www.gtap.agecon.purdue.edu/resources/res_display.asp?RecordID=5515 (Accessed: April 7, 2023).

Humaira Jamshed, P.D. (2022) Effectiveness of early time-restricted eating for weight loss and fat loss in adults with obesity, JAMA Internal Medicine. JAMA Network. Available at: https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2794819 (Accessed: April 7, 2023).

Dennis Freuer a b et al. (2021) Impact of body composition on covid-19 susceptibility and severity: A two-sample multivariable Mendelian randomization study, Metabolism. W.B. Saunders. Available at: https://www.sciencedirect.com/science/article/pii/S0026049521000329 (Accessed: April 7, 2023).

Petersen, A. et al. (2020) Obesity and covid-19: The role of visceral adipose tissue, medRxiv. Cold Spring Harbor Laboratory Press. Available at: https://www.medrxiv.org/content/10.1101/2020.05.14.20101998v1 (Accessed: April 7, 2023).

Albashir, A.A.D. (2020) The potential impacts of obesity on covid-19, Clinical medicine (London, England). U.S. National Library of Medicine. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385759/ (Accessed: April 7, 2023).

Sjögren, L. et al. (no date) Impact of obesity on intensive care outcomes in patients with COVID-19 in Sweden-A cohort study, PLOS ONE. Public Library of Science. Available at: https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0257891 (Accessed: April 7, 2023).