Platelet-rich plasma (PRP) therapy has emerged as a promising regenerative treatment in orthopedics due to its potential to accelerate tissue healing and reduce inflammation. PRP is an autologous concentration of platelets in a small volume of plasma, rich in growth factors that stimulate cell proliferation, angiogenesis, and tissue regeneration. This paper reviews the mechanisms of PRP action, preparation methods, and its clinical applications in the management of various orthopedic conditions, including osteoarthritis, tendinopathies, and ligament injuries. The safety profile, benefits, and limitations of PRP therapy are also discussed.

platelet-rich plasma, PRP therapy, orthopedic diseases, regenerative medicine, tendinopathy, osteoarthritis, growth factors, musculoskeletal injuries.

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