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https://doi.org/10.55640/
PHARMACEUTICAL INSTITUTE OF EDUCATION AND RESEARCH
Yokubova Nargiza Bakhodir kizi,Bagdasarova E.S. , Department: PharmacologyAbstract
Master's thesis on the topic: 'Study of Cognitive Abilities of the Organism Under Stress and Their Correction Using a Magnesium-Based Biocomplex.'
Keywords: cognitive abilities, memory, adaptation, stress, ultrasound, nootropics, magnesium, curcumin, glycine, cortisol, lactate dehydrogenase, ALT and AST.
Relevance of the topic: Currently, the number of stress factors in society is increasing, and the problem of personal stress resistance is becoming more relevant. Stress usually affects all aspects of cognitive activity, including such basic intellectual properties as memory and attention. Disruption of attention indicators is primarily due to the formation of a stress dominant in the cerebral cortex, which inhibits the concentration of voluntary attention on other objects and contributes to increased distractibility, as well as impairs memory and adaptation functions. The hormonal background altered by stress introduces disruptions in the process of reproducing necessary information.
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Conduct a literature review on the impact of ultrasound stress on cognitive functions.
Review the adaptogenic, neuroprotective, antidepressant, and antioxidant properties of magnesium, curcumin, and glycine.
Select 24 healthy laboratory mice of both sexes, weighing 18–22g, place them in quarantine for 14 days, and standardize them by fasting for one day before the experiment.
Divide the mice into four groups: three exposed to stress, one control group. Glycine will be used to compare the effects of the biocomplex under stress.
Create a stress model for 3 days, then begin stress correction using the biocomplex and glycine.
Assess results on days 1 and 20 of the experiment. Analyze blood cortisol and magnesium levels, and test animals using the “open field” and “maze” methods to assess cognitive abilities.
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