Graft-versus-host disease (GVHD) is a major complication following allogeneic haematopoietic stem cell transplantation (HSCT) in patients with severe aplastic anaemia (SAA). Unlike patients with malignant haematologic diseases, SAA patients derive no graft-versus-leukaemia benefit from GVHD, making its prevention and management critically important. This study aimed to analyse the incidence, clinical features, and outcomes of GVHD in patients with aplastic anaemia who underwent HSCT at the Samarkand Regional Haematology Centre between 2019 and 2023. A total of 42 patients were included. Acute GVHD developed in 42.9% of patients, with severe forms (Grade III–IV) in 21.4%. Chronic GVHD occurred in 23.8%, often presenting with autoimmune-like features. The skin, gastrointestinal tract, and liver were the most commonly affected organs. GVHD was more common and severe in patients with unrelated donors and in those receiving peripheral blood stem cells. Most patients responded to corticosteroid therapy; however, a subset required second-line immunosuppressants. The one-year overall survival rate was 85.7%, with GVHD-related mortality in 7.1% of cases. These findings highlight the need for vigilant GVHD prevention, early diagnosis, and risk-adapted immunosuppressive treatment strategies in aplastic anaemia patients undergoing HSCT.

Aplastic anaemia, haematopoietic stem cell transplantation, graft-versus-host disease, acute GVHD, chronic GVHD, immunosuppressive therapy, unrelated donor, peripheral blood stem cells, Uzbekistan.

Marsh, J. C. W., Ball, S. E., Cavenagh, J., Darbyshire, P., Dokal, I., Gordon-Smith, E. C., Killick, S. B., Porter, J., & Tighe, J. E. (2010). Guidelines for the diagnosis and management of aplastic anaemia. British Journal of Haematology, 147(1), 43–70. https://doi.org/10.1111/j.1365-2141.2009.07842.x

Passweg, J. R., Baldomero, H., Bader, P., Bonini, C., Duarte, R. F., Dufour, C., Gennery, A. R., Kröger, N., Kuball, J., & Lankester, A. (2019). Hematopoietic stem cell transplantation in Europe 2017: More than 45,000 transplants annually. Bone Marrow Transplantation, 54(6), 842–850. https://doi.org/10.1038/s41409-019-0469-5

Locatelli, F., Algeri, M., & Oliveira, M. C. (2019). Hematopoietic stem cell transplantation for aplastic anemia in children and adolescents. Biology of Blood and Marrow Transplantation, 25(7), e139–e147. https://doi.org/10.1016/j.bbmt.2019.02.020

Jagasia, M. H., Greinix, H. T., Arora, M., Williams, K. M., Wolff, D., Cowen, E. W., Palmer, J., Treister, N. S., Cheng, G. S., & Kerr, H. (2015). National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report. Biology of Blood and Marrow Transplantation, 21(3), 389–401. https://doi.org/10.1016/j.bbmt.2014.12.001

Zeiser, R., & Blazar, B. R. (2017). Acute Graft-versus-Host Disease—Biologic Process, Prevention, and Therapy. New England Journal of Medicine, 377(22), 2167–2179. https://doi.org/10.1056/NEJMra1609337

Dufour, C., & Pillon, M. (2015). Management of aplastic anaemia in children and adolescents: Current perspectives. Paediatric Drugs, 17(2), 91–100. https://doi.org/10.1007/s40272-015-0123-1

Makhmonov, L. S., Temirov, N. N., Shomurodov, K. E., & Amerova, D. A. (2024). Aplastik anemiyali bemorlarda HSCTdan keyingi GVHDning klinik kechishi. O‘zbekiston Tibbiyoti va Gematologiya Jurnali, 2(1), 35–42.

Gazkhanovna, M. A., Makhmatovich, A. K., & Utkirovich, D. U. (2022). Clinical efficacy of extracorporeal and intravascular hemocorrection methods in psoriasis. ACADEMICIA: An International Multidisciplinary Research Journal, 12(2), 313-318.

Мадашева, А. Г. (2022). Коррекция диффузной алопеции при железодефицитной анемии. Science and Education, 3(12), 231-236.

Мадашева, А. Г., & Жураева, М. З. (2019). Биохимические показатели и комплексное лечение больных псориазом с лечебным плазмаферезом. Достижения науки и образования, (10 (51)), 78-82.

Turdiyev, Q., Maxmonov, L., Xaqberdiyev, Z., & Madasheva, A. (2025). FEATURES OF MAINTAINING RENAL FAILURE IN PATIENTS WITH DIABETES MELLITUS ON GEODIALYSIS. International Journal of Artificial Intelligence, 1(1), 1481-1486.

Мадашева, А. Г., Бергер, И. В., Махмудова, А. Д., Абдиев, К. М., & Амерова, Д. A. (2025). Самаркандский государственный медицинский университет, Самарканд, Узбекистан 2 Республиканский специализированный научно-практический медицинский центр гематологии, Ташкент, Узбекистан. Laboratory Diagnostics Eastern Europe, 87.

Бергер, И. В., Махмудова, А. Д., Мадашева, А. Г., & Ходжаева, Н. Н. (2023). ПОЛИМОРФИЗМ ПРОВОСПАЛИТЕЛЬНЫХ ЦИТОКИНОВ В ГЕНЕЗЕ ТРОМБООБРАЗОВАНИЯ ПРИ ТРОМБОФИЛИИ И АФС. Журнал гуманитарных и естественных наук, (5), 43-46.