Articles | Open Access | https://doi.org/10.55640/

METHODS FOR CORRECTING CARDIAC RHYTHM DISORDERS IN LEUKEMIC INTOXICATION

Dilafruz Abdikhalimovna Amerova,Bobirjon Makhmudovich Abdirayimov , Samarkand State Medical University, Samarkand, Uzbekistan

Abstract

Leukemic intoxication often leads to serious complications, including cardiac rhythm disturbances, which significantly affect patient outcomes. This study investigates the effectiveness of different treatment strategies for correcting arrhythmias in patients with leukemia experiencing intoxication-related complications. Forty-eight patients diagnosed with leukemia and presenting with ECG-confirmed rhythm disorders were enrolled. They were divided into two groups: one received standard antiarrhythmic therapy, while the other received an integrated treatment that included detoxification, correction of electrolyte imbalances, and cardioprotective agents in addition to antiarrhythmic drugs. Clinical and diagnostic assessments, including ECG and biochemical testing, were used to evaluate treatment efficacy. The integrated approach resulted in a significantly higher rate of rhythm normalization and faster symptom relief compared to standard therapy alone. These findings suggest that addressing the systemic toxic effects of leukemia in combination with conventional cardiological treatment provides a more effective strategy for correcting rhythm disturbances in these patients.

Keywords

Leukemia, arrhythmia, leukemic intoxication, rhythm correction, antiarrhythmic therapy, detoxification, electrolyte balance, cardioprotection.

References

Wang, Y., Zhang, L., & Li, H. (2021). Cardiotoxic effects of chemotherapy and leukemic infiltration: Pathophysiology and clinical implications. Journal of Hematology & Oncology, 14(1), 210–216. https://doi.org/10.1186/s13045-021-01101-8

Mishra, P., Gupta, A., & Singh, S. (2019). Cardiac manifestations in patients with leukemia: A prospective clinical study. Indian Heart Journal, 71(2), 112–118. https://doi.org/10.1016/j.ihj.2019.03.002

Dincer, A., & Gungor, H. (2018). Arrhythmias in hematologic malignancies: The role of electrolyte imbalance and inflammation. Clinical Hematology International, 10(3), 156–164. https://doi.org/10.1016/j.chi.2018.05.006

Al-Mushayt, A., & Al-Ghamdi, S. (2020). Use of trimetazidine and CoQ10 in preventing chemotherapy-induced cardiotoxicity. Cardio-Oncology Reports, 5(4), 88–94.

Heidenreich, P. A., et al. (2022). 2022 AHA/ACC/HRS guideline for the management of patients with ventricular arrhythmias. Circulation, 146(15), e272–e391. https://doi.org/10.1161/CIR.0000000000001106

Kuznetsov, S. V., & Ivanova, T. A. (2021). Clinical approaches to treating cardiac complications in haematological patients. Russian Journal of Cardiology, 26(8), 95–101.

National Cancer Institute. (2023). Cardiotoxicity and Cancer Therapy. Retrieved from https://www.cancer.gov/about-cancer/treatment/side-effects/cardiotoxicity

Gazkhanovna, M. A., Makhmatovich, A. K., & Utkirovich, D. U. (2022). Clinical efficacy of extracorporeal and intravascular hemocorrection methods in psoriasis. ACADEMICIA: An International Multidisciplinary Research Journal, 12(2), 313-318.

Мадашева, А. Г. (2022). Коррекция диффузной алопеции при железодефицитной анемии. Science and Education, 3(12), 231-236.

Мадашева, А. Г., & Жураева, М. З. (2019). Биохимические показатели и комплексное лечение больных псориазом с лечебным плазмаферезом. Достижения науки и образования, (10 (51)), 78-82.

Ruziboeva, O. N., Abdiev, K. M., Madasheva, A. G., & Mamatkulova, F. K. (2021). Modern Methods Of Treatment Of Hemostasis Disorders In Patients With Rheumatoid Arthritis. Ученый XXI века, 8.

Мадашева, А. Г., Дадажанов, У. Д., Абдиев, К. М., Маматкулова, Ф. Х., & Махмудова, А. Д. (2019). Динамика электронейромиографических показателей и эффективность электрической стимуляции мышц у больных гемофилией с мышечными атрофиями. Достижения науки и образования, (10 (51)), 26-30.

Article Statistics

Downloads

Download data is not yet available.

Copyright License

Download Citations

How to Cite

METHODS FOR CORRECTING CARDIAC RHYTHM DISORDERS IN LEUKEMIC INTOXICATION. (2025). International Journal of Medical Sciences, 5(05), 266-270. https://doi.org/10.55640/