Research and technological advancements in the field of artificial blood (bio-blood) production are paving the way for new opportunities in medicine. This article discusses the types of artificial blood, production technologies, clinical trials, and future prospects. The main types of artificial blood, including oxygen-carrying preparations, plasma substitutes, and blood component replacement materials, are examined. Additionally, the article highlights the technologies involved in artificial blood production, the stages of clinical trials, and research focused on ensuring the safety and efficacy of artificial blood. Future prospects for the widespread clinical use of artificial blood and its role in improving healthcare in developing countries are also explored. This article summarizes the scientific research and technological breakthroughs in the field of artificial blood and provides a detailed analysis of its future prospects.

Artificial blood production, bio-blood, oxygen transport molecules, clinical trials, blood substitutes, biotechnology, genetic modification, prospects of artificial blood production.

Winslow, R. M., & Gonzales, A. (2012). Artificial blood substitutes: Challenges and opportunities. Current Opinion in Hematology, 19(6), 526–533. https://doi.org/10.1097/MOH.0b013e328359f5b3

Natanson, C., Kern, S. J., Lurie, P., Banks, S. M., & Wolfe, S. M. (2008). Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: A meta-analysis. Journal of the American Medical Association, 299(19), 2304–2312. https://doi.org/10.1001/jama.299.19.2304

Chang, T. M. S. (2006). Hemoglobin-based red blood cell substitutes. Artificial Cells, Blood Substitutes, and Biotechnology, 34(6), 533–545. https://doi.org/10.1080/10731190600963953

Bian, Y., Wang, M., & Liu, J. (2020). Advances in artificial blood research: An overview. Frontiers in Bioengineering and Biotechnology, 8, 634. https://doi.org/10.3389/fbioe.2020.00634

Moore, E. E., Moore, H. B., Chapman, M. P., Gonzalez, E., Slaughter, A., Morton, A. P., & Sauaia, A. (2015). Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: A randomised trial. The Lancet, 389(10076), 310–319. https://doi.org/10.1016/S0140-6736(17)30038-0