Articles | Open Access | https://doi.org/10.55640/

CORRECTION OF MORPHOFUNCTIONAL ALTERATIONS IN SALIVARY GLANDS INDUCED BY CONSUMPTION OF HARD ALKALINE GROUNDWATER USING CITRIC ACID SUPPLEMENTATION

Teshaeva Dilbar Shukhratovna , Assistant of the Department of Anatomy and Clinical Anatomy (OHTA), Bukhara State Medical Institute named after Abu Ali ibn Sina.

Abstract

The chronic consumption of hard, alkaline groundwater has been associated with morphofunctional changes in salivary glands, potentially impairing oral health and glandular secretory activity. This study investigates the corrective effect of citric acid supplementation on the structure and function of salivary glands in individuals consuming such water sources. Histological examination, salivary pH, and flow rate analysis were conducted in experimental models to assess glandular morphology and function. Results demonstrated that citric acid mitigates structural alterations and restores near-normal secretory function, suggesting its potential as a simple, accessible corrective measure for populations reliant on mineral-rich groundwater.

Keywords

Salivary glands, groundwater, hardness, alkalinity, citric acid, morphofunctional changes, oral health

References

Kim, H. et al. (2019). Citric acid and its role in oral pH regulation. Int J Dent Sci, 14(2), 78–85.

Olsufyeva A.V., Timofeeva M.O., Vovkogon A.D., Chairkin I.N. (2017). Features of the morphology of the initial sections of the lingual glands. Morphological Bulletin, 25(2), 54–56. https://doi.org/10.20340/mv-mn.17(25).02.10

Sapin M.R., Nikityuk D.B., Litvinenko L.M. (2013). Atlas of Human Anatomy for Dentists. Moscow: GEOTAR-Media. 600 p.

Smith, J. et al. (2020). The effect of water hardness on salivary gland physiology. J Oral Biol, 45(3), 123-130.

Teshayeva D.Sh., Khasanova D.A. (2024). Influence of external factors on the salivary glands. European Journal of Modern Medicine and Practice, 4(12). https://inovatus.es/index.php/ejmmp/article/view/4775

Orekhov S.N., Matveev S.V., Karakyan A.E., Ibragimova E.Z. (2017). Causes of salivary gland secretion disorders and treatment methods. Scientific Review. Medical Sciences, 4, 58–64.

Shevchenko K.V., Eroshenko G.A., Solod A.V., Lisachenko O.D., Yakushko O.S., et al. (2020). Correlation analysis of metric parameters of the parenchymal components of submandibular glands in rats after ethanol exposure. World of Medicine and Biology, 2020.

Habibova N.N. (2019). A diagnostic approach for early detection of chronic recurrent aphthous stomatitis using biochemical and immunological indicators of mixed saliva. Certificate No. DGU 6506 (23.05). https://scholar.google.ru/...JIC

Habibova N.N., Avezova S.M. (2019). Characteristics of lipid peroxidation processes and antioxidant activity of saliva in the oral cavity in chronic recurrent aphthous stomatitis. Biology and Integrative Medicine, 112–121. https://scholar.google.ru/...FkC

Teshayeva D.Sh., Khasanova D.A. (2024). The effect of external factors on the salivary glands (literature review). Uzbekistan Military Medical Journal, Issue 5.

Kozlova M.V., Vasiliev A.Yu., Arutyunyan B.A. (2019). Capacity of salivary glands. International Journal of Biomedicine, 9(1), 26–30. https://doi.org/10.21103/article9(1)_OA4

Teshayeva D.Sh. (2025). Morphology of the salivary glands. Web of Science: Medicine, Practice and Nursing, 3(2), 235–238. https://webofjournals.com/index.php/5/article/view/3231

Qodirov O.O. (2024). With the physiological-chemical process observed in the body under the influence of water. Scientific Journal of Applied and Medical Sciences, 3(6), 209–211. https://scholar.google.com/...hoC

Qodirov O.O. (2024). The importance of water with different chemical composition in cell proliferation. International Journal of Alternative and Contemporary Therapy, 2(6), 53–54. https://scholar.google.com/.

Teshayeva D.Sh. (2025). On the importance of studying salivary glands. Oriental Journal of Medicine and Natural Science. https://innoworld.net/index.php/ojmns/article/view/323

. Teshayeva D.Sh., Khasanova D.A. (2024). Influence of external factors on the salivary glands. New Day in Medicine, 12(74), 455–458. https://newdayworldmedicine.com/en/new_day_medicine/12-74-2024

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CORRECTION OF MORPHOFUNCTIONAL ALTERATIONS IN SALIVARY GLANDS INDUCED BY CONSUMPTION OF HARD ALKALINE GROUNDWATER USING CITRIC ACID SUPPLEMENTATION. (2025). International Journal of Medical Sciences, 5(05), 462-466. https://doi.org/10.55640/