Cytostatic drugs are essential in the treatment of rheumatoid polyarthritis (RA) but often cause cytostatic disease, manifesting as toxic effects on the liver, gastrointestinal system, and bone marrow. This study aimed to evaluate the effectiveness of different correction strategies for cytostatic disease in RA patients. Sixty patients were randomly assigned to three groups: Group I received standard supportive therapy (vitamins B1, B6, and folic acid); Group II received the same with added adaptogens (Rhodiola rosea and Eleutherococcus); and Group III received antioxidant-enzyme therapy (alpha-lipoic acid and glutathione) in addition to the standard protocol. After 12 weeks, all groups showed clinical improvement, but Group III demonstrated the most significant reductions in toxicity symptoms and normalization of haematological and liver parameters. Importantly, disease activity remained stable across all groups. These findings suggest that antioxidant-enzyme therapy is a highly effective approach to correcting cytostatic disease in RA without compromising the underlying antirheumatic treatment.

Rheumatoid polyarthritis; cytostatic disease; antioxidant therapy; adaptogens; alpha-lipoic acid; glutathione; supportive therapy; toxicity correction; inflammation; clinical outcomes.

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