Immune thrombocytopenia (ITP) during pregnancy presents significant diagnostic and therapeutic challenges due to the potential risks to both mother and fetus. This study aimed to develop and validate a clinical protocol for the diagnosis and management of ITP in pregnant patients. A total of 62 pregnant women with confirmed ITP were treated according to a stepwise protocol involving initial corticosteroid therapy, intravenous immunoglobulin (IVIG) for corticosteroid-resistant or contraindicated cases, and second-line agents for refractory patients. Diagnostic workup excluded other causes of thrombocytopenia, ensuring accurate diagnosis. The protocol demonstrated high efficacy with favorable maternal and neonatal outcomes, including minimal bleeding complications and safe delivery conditions. Corticosteroids and IVIG were generally well tolerated, though careful monitoring for adverse effects was necessary. This protocol provides a practical, evidence-based framework for managing ITP during pregnancy, improving treatment outcomes and patient safety. Further studies are recommended to optimize therapy and long-term follow-up.

Immune thrombocytopenia, pregnancy, clinical protocol, corticosteroids, intravenous immunoglobulin, diagnosis, treatment, maternal outcomes, neonatal outcomes, refractory ITP

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