Articles | Open Access | https://doi.org/10.55640/

USING OZONOTHERAPY ON THE TREATMENT OF EYE DISEASES (LITERATURE REVIEW)

Bekmurodova Orzigul Kamolovna , Senior Lecturer of the Department of Ophthalmology, Bukhara State Medical Institute named after Abu Ali Ibn Sino, Bukhara, Uzbekistan.

Abstract

Ozonetherapy is gaining attention in ophthalmology as a potential treatment for various eye conditions due to its anti-inflammatory, bactericidal, and circulatory benefits. Early uses in veterinary medicine show promise, particularly for anterior segment diseases, suggesting ozone could help reduce inflammation and infections in the eye. Studies and reviews have explored ozone therapy's application for eye diseases, noting different methods for administration, such as topical use and systemic delivery. Evidence suggests it may be effective for age-related macular degeneration (AMD), with some studies indicating improvements in visual acuity. Ozone therapy is also examined for other inflammatory conditions and wound healing, but has possible side effects, like burning eyes. While ozone can be beneficial, environmental exposure can worsen dry eye symptoms. Stabilized ozonated oils may offer a safer application for treatment. More extensive clinical trials are needed to establish standardized protocols and ensure safe usage.

Keywords

Ozonetherapy, dry eye syndrome, anterior segment, age-related macular dystrophy.

References

Spadea L, Tonti E, Spaterna A, Marchegiani A. Use of Ozone-Based Eye Drops: A Series of Cases in Veterinary and Human Spontaneous Ocular Pathologies. Case Rep Ophthalmol. 2018 May 24;9(2):287-298. doi: 10.1159/000488846. PMID: 29928225; PMCID: PMC6006625.

Borrelli E, Bocci V. Visual improvement following ozonetherapy in dry age related macular degeneration; a review. Med Hypothesis Discov Innov Ophthalmol. 2013 Summer;2(2):47-51. PMID: 24600642; PMCID: PMC3939750.

Riva Sanseverino, E., Meduri, R. A., Pizzino, A., Prantera, M., & Martini, E. (1990). Effects of oxygen-ozone therapy on age-related degenerative retinal maculopathy. Panminerva medica, 32(2), 77–84.

Kim, Y., Paik, H. J., Kim, M. K., Choi, Y. H., & Kim, D. H. (2019). Short-Term Effects of Ground-Level Ozone in Patients With Dry Eye Disease: A Prospective Clinical Study. Cornea, 38(12), 1483–1488. https://doi.org/10.1097/ICO.0000000000002045

Seen, S., & Tong, L. (2018). Dry eye disease and oxidative stress. Acta ophthalmologica, 96(4), e412–e420. https://doi.org/10.1111/aos.13526

Aydoğan, S., Erol, H., & Baran, M. (2023). Effects of ozone therapy on acidic corneal burns in rats. Veterinary research forum : an international quarterly journal, 14(4), 195–199. https://doi.org/10.30466/vrf.2022.551199.3432

Travagli V. (2022). Some clarifications regarding ozone therapy vs retinal vascular reactivity. Photodiagnosis and photodynamic therapy, 40, 103140. https://doi.org/10.1016/j.pdpdt.2022.103140

Kaya, A., Sonmez, M., Kar, T., Haholu, A., Yildirim, Y., Müftüoğlu, T., & Ünal, M. H. (2017). Efficiency of Ozone Therapy in a Rat Model of Experimental Uveitis. Ocular immunology and inflammation, 25(5), 695–700. https://doi.org/10.3109/09273948.2016.1161057

Varol, K., Koç, A. N., Çakır Bayram, L., Arda, H., Keleş, İ., Ünlü, M., Güneş, V., Ekinci, G., Karaca Bekdik, İ., & Atalay, M. A. (2022). Studies on the Effectiveness of Ozone Therapy on the Treatment of Experimentally Induced Keratitis with Candida albicans in Rabbits. Seminars in ophthalmology, 37(2), 253–264. https://doi.org/10.1080/08820538.2021.1995006

Gierek-Lapińska, A., Antoszewski, Z., Myga, B., & Skowron, J. (1992). Wstepne doniesienie o stosowaniu ozonoterapii ogólnej w schorzeniach tylnego bieguna gałki ocznej [Preliminary report on using general ozone therapy in diseases of the posterior segment of the eye]. Klinika oczna, 94(5-6), 139–140.

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USING OZONOTHERAPY ON THE TREATMENT OF EYE DISEASES (LITERATURE REVIEW). (2025). International Journal of Medical Sciences, 5(06), 61-64. https://doi.org/10.55640/