Nonsteroidal anti-inflammatory drugs belong to the most widely used medications. This work is devoted to studying the effect of benzoic acid derivatives diphenyl-/bis-(benzoyloxy)/-silone and 1,4-bis-(bromobenzoyloxy)-butyne-2 on the exudative and proliferative phases of inflammation. Experiments conducted on animals showed that the mechanism of the anti-inflammatory action of the studied chemical compounds is associated with inhibition of the exudative and proliferative phases of the inflammatory process. 

inflammation, anti-inflammatory effect, analgesic effect, antipyretic effect, benzoic acid derivative, mechanism of anti-inflammatory action, antiexudative effect, antiproliferative effect, antiallergic effect.

Asfandiyarova N.S., Philippov E.V. The use of nonsteroidal anti-inflammatory drugs in polymorbid pathology // Ter Arkh. – 2020. – Jan 15; (1). – Р. 82-88.

Barkin R.L. Topical Nonsteroidal Anti-Inflammatory Drugs: The Importance of Drug, Delivery, and Therapeutic Outcome // Am J Ther. – 2015. Sep-Oct; 22(5). – Р. 388-407.

Bindu S., Mazumder S., Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective // Biochem. Pharmacol. – 2020. - Oct:180. - Р. 114-147.

Gunaydin C., Bilge S. S. Effect of nonsteroidal anti- inflammatory drugs at the molecular level // Eurasian J. Med. – 2018. - №50. – Р. 116 —121.

Honvo G., Leclercq V., Geerinck A., Thomas T., Veronese N., Charles A., Rabenda V., Beaudart C., Cooper C., Reginster J.Y. et al. Safety of Topical Non-steroidal Anti-Inflammatory Drugs in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis // Drugs Aging. – 2019.- 36 (Suppl. 1). – Р. 45–64.

Hunter L.J., Wood D.M., Dargan P.I. The patterns of toxicity and management of acute nonsteroidal anti-inflammatory drug (NSAID) overdose // Open Access Emerg Med. – 2011. - №3. – Р. 39-48.

Kabulov Sh.M., Makhsumov Sh.M., Zaitseva O.A., Muratkhanova D.A., Khasanova D.A. Anti-inflammatory, analgesic and antipyretic activity of the drug 1,4-bis-(bromobenzoyloxy)-butine-2 // Dermatovenereology and aesthetic medicine. - 2015. - No. 2. - P. 106-109.

Kate R.J., Perez R.M., Mazumdar D., Pasupathy K.S., Nilakantan V. Prediction and detection models for acute kidney injury in hospitalized older adults // BMC Med Inform Decis Mak. - 2016. (16). Р. 39.

Makhsumov Sh.M., Zaytseva O.A. On the mechanism of action and some toxicological characteristics of the drug 3,4-bis-(2,4-dinitrobenzoyloxymethyl)-pyrazole // Electronic Innovation Bulletin. - 2018. - No. 1. – pp. 14–15.

Makhsumov Sh.M., Zaytseva O.A. Anti-inflammatory activity of a new benzoic acid derivative diphenyl-/bis-(benzoyloxy)/-silone // FEN-SCIENCE. Periodical journal of scientific works. – 2015. - No. 6 (45). – pp. 41-44.

Makhsumov Sh.M., Zaytseva O.A., Mamajanova M.A. The mechanism of the anti-inflammatory action of some pyrazole derivatives // Electronic Innovation Bulletin. - 2018. - No. 1. – pp. 12–13.

Nagesh Kishan Panchal, Evan Prince Sabina. Non-steroidal anti-inflammatory drugs (NSAIDs): A current insight into its molecular mechanism eliciting organ toxicities // Food and Chemical Toxicology. – 2023. - Volume 172. – Р. 113598.

Rinott E., Kozer E., Shapira Y., Bar-Haim A., Youngster I. Ibuprofen use and clinical outcomes in COVID-19 patients. // Clin. Microbiol. Infect. - 2020. -№26(9). – Р. 1259 е5-1259 е7.

Sandu R.E., Uzoni A., Coman C., Popa-Wagner A. Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment // Rom J Morphol Embryol. - 2015. - №56. – Р. 1111-1117.

Shekelle P.G., Newberry S.J., FitzGerald J.D., Motala A., O'Hanlon C.E., Tariq A., Okunogbe A., Han D., Shanman R. Management of Gout: A Systematic Review in Support of an American College of Physicians Clinical Practice Guideline // Ann Intern Med. – 2017. - №166(1). – Р. 37-51.

Yakubova L.K., Chirko M.Yu. , Makhsumov Sh.M., Zaytseva O.A. Some mechanisms of the anti-inflammatory action of the drug 3,4-bis-(2-bromobenzoyloxymethyl)-pyrazole // Bulletin of the Tashkent Medical Academy. - 2013. - No. 1. - P. 31-35.