Articles
| Open Access |
https://doi.org/10.55640/
THE RELATIONSHIP BETWEEN METABOLIC SYNDROME AND ARTERIAL HYPERTENSION: PATHOGENESIS, DIAGNOSIS, AND TREATMENT APPROACHES
Mavlonov Namoz Xalimovich , Associate Professor, Department of Internal Medicine in Family Medicine, Bukhara State Medical Institute named after Abu Ali Ibn Sina, PhDAbstract
Metabolic syndrome and arterial hypertension are currently among the most serious and pressing issues in global healthcare. These two conditions frequently coexist and significantly increase the risk of cardiovascular diseases, decreased insulin sensitivity, and the development of type 2 diabetes. This article explores the interrelation between these conditions, their pathophysiological mechanisms, diagnostic criteria, and modern treatment approaches.
Keywords
Cardiovascular diseases, metabolic syndrome, arterial hypertension, insulin resistance, treatment.
References
Alberti, K. G., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., ... & Smith, S. C. (2009). Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Circulation, 120(16), 1640–1645. https://doi.org/10.1161/CIRCULATIONAHA.109.192644
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004). Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference. Circulation, 109(3), 433–438. https://doi.org/10.1161/01.CIR.0000111245.75752.C6
Reaven, G. M. (1988). Banting lecture 1988. Role of insulin resistance in human disease. Diabetes, 37(12), 1595–1607. https://doi.org/10.2337/diab.37.12.1595
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., ... & Ruilope, L. M. (2013). 2013 ESH/ESC Guidelines for the management of arterial hypertension. Journal of Hypertension, 31(7), 1281–1357. https://doi.org/10.1097/01.hjh.0000431740.32696.cc
Kaur, J. (2014). A comprehensive review on metabolic syndrome. Cardiology Research and Practice, 2014, 943162. https://doi.org/10.1155/2014/943162
DeFronzo, R. A., & Ferrannini, E. (1991). Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care, 14(3), 173–194. https://doi.org/10.2337/diacare.14.3.173
Esser, N., Paquot, N., & Scheen, A. J. (2015). Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease. Expert Opinion on Investigational Drugs, 24(3), 283–307. https://doi.org/10.1517/13543784.2015.985290
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey Jr, D. E., Collins, K. J., Dennison Himmelfarb, C., ... & Wright Jr, J. T. (2018). 2017 ACC/AHA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults. Journal of the American College of Cardiology, 71(19), e127–e248. https://doi.org/10.1016/j.jacc.2017.11.006
Article Statistics
Downloads
Copyright License
This work is licensed under a Creative Commons Attribution 4.0 International License.