This review analyzes the distinctive features of the clinical course and diagnosis of pyodermas in patients with significant immunocompromising conditions, namely Human Immunodeficiency Virus (HIV) infection and Diabetes Mellitus (DM). It explores the characteristic clinical presentations, predominant causative pathogens, and their patterns of antimicrobial resistance. The article highlights the challenges in differential diagnosis and proposes an optimized framework for managing these complex patients. The urgency of this topic is underscored by the growing global prevalence of immunocompromised individuals and the concurrent shift in the clinical presentation of dermatoses within this population, demanding advanced knowledge and a re-evaluation of traditional therapeutic approaches by dermatologists and infectious disease specialists.

pyoderma, immunodeficiency, HIV infection, diabetes mellitus, Staphylococcus aureus, MRSA, atypical presentation, diagnosis, antibiotic resistance, skin infection.

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