Osteoporosis is a chronic systemic metabolic disease of the skeleton, which is characterized by a progressive decrease in bone mass. The predominance of resorption processes and a decrease in bone formation it lead to a violation of bone microarchitecture and its shrinkage. Currently, osteoporosis and associated bone fractures are one of the main causes of disability and premature death in the elderly [1]. One of the main causes of osteoporosis is a violation of the hormonal background, which has been studied by many scientists. In particular, impaired activity of testosterone, estrogen, melatonin affects osteons.

osteoporosis, testosterone, estrogen, melatonin, menopause

Sambrook P., Cooper C. Osteoporosis. Lancet 2006;367:2010–8.

file:///C:/Users/User/Downloads/osteoporoz-v-obscheterapevticheskoy-praktike-ot-diagnosticheskoy-gipotezy-k-differentsialnomu-diagnozu.pdf

De Souza M.J., Nattiv A., Joy E., Misra M., Williams N.I., Mallinson R.J., Gibbs J.C. et al. Female Athlete Triad Coalition consensus statement on treatment and return to play of the female athlete triad: 1st International Conference held in San Francisco, CA, May 2012, and 2nd International Conference held in Indianapolis in May 2013 // Clin. J Sport Med. – 2014. – Vol. 24 (2). – P. 96–119. DOI: 10.1136/bjsports-2013-093218 15. Mountjoy M., Sundgot-Borgen J., Burke L., Carter S., Constantini N., Lebrun C. et al. The IOC consensus statement: beyond the Female Athlete Triad--Relative Energy Deficiency in Sport (RED-S) // Br J Sports Med. – 2014. – Vol. 48 (7). – P. 491-497. DOI: 10.1136/ bjsports-2014-093502

Sims N. A., Martin T. J. Osteoclasts Provide Coupling Sig nals to Osteoblast Lineage Cells Through Multiple Mecha nisms. Annual Rev. Physiol. 2020;82:507-529. https://doi.org/10.1146/annurev-physiol-021119-034425

Chen H., Senda T., Kubo K. Y. The osteocyte plays mul tiple roles in bone remodeling and mineral homeostasis. Medical Molecular Morphology. 2015;48(2):61-68. https://doi.org/10.1007/s00795-015-0099-y

file:///C:/Users/User/Desktop/%D0%BA%D0%B8%D1%82%D0%BE%D0%B1%D0%BB%D0%B0%D1%80/vliyanie-melatonina-na-reparativnuyu-regeneratsiyu-kostnoy-tkani-chelyustnyh-kostey-v-eksperimente.pdf

file:///C:/Users/User/Desktop/%D0%BA%D0%B8%D1%82%D0%BE%D0%B1%D0%BB%D0%B0%D1%80/vliyanie-melatonina-na-reparativnuyu-regeneratsiyu-kostnoy-tkani-chelyustnyh-kostey-v-eksperimente.pdf

Влияние мелатонина на репаративную регенерацию костной ткани челюстных костей в эксперименте Е. В. Щетинин , Е. С. Сирак , Г. А. Афанасьева , Г. Г. Петросян , Е. Е. Щетинина , С. В. Сирак

СТАРЕНИЕ КОСТНОЙ ТКАНИ Браилова Н.В.1, Кузнецова В.А.2, Дудинская Е.Н.1, Ткачева О.Н.

file:///C:/Users/User/Desktop/%D0%BA%D0%B8%D1%82%D0%BE%D0%B1%D0%BB%D0%B0%D1%80/starenie-kostnoy-tkani.pdf

Reid I.R., Miller P.D., Brown J.P., et al. Effects of denosumab on bone histomorphometry: The FREEDOM and STAND studies. J Bone Miner Res. 2010; 25(10): 2256–2265. DOI: 10.1002/ jbmr.149.n

Tordjman S., Chokron S., Delorme R., Charrier A., Bellissant E., Jaafari N. Fougerou C. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Current Neuropharmacology. 2017;15(3):434–443. https://doi.org/10.2174/ 1570159X14666161228122115. 2.

Pandi- Perumal S.R., Srinivasan V., Maestroni G.J.M., Cardinali D.P., Poeggeler B., Hardeland R. Melatonin: Nature’s most versatile biological signal? FEBS J. 2006;273(13):2813–2838. https://doi.org/10.1111/j.1742-4658.2006.05322.x.

Arendt J. Melatonin and human rhythms. Chronobiol Int. 2006;23(1–2)9:21–37. https://doi.org/10.1080/07420520500464361.

Tordjman S., Chokron S., Delorme R., Charrier A., Bellissant E., Jaafari N. Fougerou C. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Current Neuropharmacology. 2017;15(3):434–443. https://doi.org/10.2174/ 1570159X14666161228122115.

Miller S.C., Pandi- Perumal S.R., Esquifino A.I., Cardinali D.P. The role of melatonin in immunoenhancement: Potential application in cancer. Int J Exp Pathol. 2006;87(2):81–87. https://doi.org/10.1111/j.0959- 9673.2006.00474.x.

Sifat Maria, Paula A. larning Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone-grafting procedures

https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12116

Влияние мелатонина на репаративную регенерацию костной ткани челюстных костей в эксперименте Е. В. Щетинин , Е. С. Сирак , Г. А. Афанасьева , Г. Г. Петросян , Е. Е. Щетинина , С. В. Сирак