Objective: to analyze the distribution of genes and genotypes of chronic kidney diseases depending on the degree of overweight and obesity.

Material and methods: 98 overweight and obese patients with chronic kidney diseases treated in various departments of the multidisciplinary medical center of the Bukhara region were examined. 30 patients formed the control group. 68 patients of the main group were divided into 3 subgroups depending on the body mass index and degree: 38 had degree I, 16 - II, 14 - III.

B.Z Djumaev. GENE AND GENOTYPE POLYMORPHISM IN PATIENTS WITH OVERWEIGHT AND OBESITY

Belskikh O.A. Osobennosti klinicheskogo techeniya i lechenie stomatologicheskikh zabolevanii pri kronicheskogo bolezni chek. - Abstract dis. k.m.n, St. Petersburg, 2016. 4. Mayborodin I.V. i. drug Sotoyanie plosti rta pri chechnoy dostatochnosti. -//Journal: Dentistry. 2014; 93(1): 72-79

Djumaev B. Z. Puti snizheniya izbytochnoi massy tela i ozhireniya pri khronicheskikh zabolevaniyakh pecheni //Scientific journal of applied and medical sciences. - 2022. - t. 1. – no. 5. - p. 100-106.

Djumaev B. Z. Sposoby Snijeniya Izbytochnogo Vesa I Ojireniya Pri Khronicheskom Zabolevanii Pecheni V Meditsinskikh Vmeshatelstvax Abu Ali Ibn Siny //scientific journal of practical and medical sciences. - 2022. - t. 1. – no. 5. - p. 94-99.

Djumaev B.Z. Determination of epidemiology of gene and genotypes determining body weight by kettle index indicator:1-5 www.iejrd.com E-ISSN NO:-2349-0721

Djumaev B.Z. Izuchenie rasprostranennosti genov i genotipov izbytochnoy massy tela pri kronicheskikh zabolevaniyax pecheni //biologiya i integrativnaya meditsina. – 2022. – no. 2 (55). - p. 95-103.

Gilmiyarova F.N., Radomskaya V.M., Kartashova O.A. and others. In ensuring the effective operation of clinical and laboratory services and the prospects for the unity of clinical medicine. // Clinical laboratory diagnostics, 2017. – #10. – B.31–32.

Kato S., Chmielewski M., Honda H., Pecoits-Filho R., Matsuo S., Yuzawa Y., Tranaeus A., Stenwinkel P., Lindholm B. Aspects of immune dysfunction in end-stage renal disease. // Clin. J. Am. Soc. Nephrol. 2008. Vol. 3, N 5. P. 1526–1533.

Komarova O.V., E.A. Sivtseva, A.S. Kudryakova, Margieva T.V.,. Obzor sovremennykh predstavlenii ob endotelialnoy disfunktsii / Natsionalnaya meditsinskaya akademiya im. P.L. Shupika: Department of Neurology, Kyiv, 2018. – #1. – S. 38–39. Welsh T.R., Beischel L. S., Frenzkl M., Witte D. Regulated expression of complement factor (in the human kidney. //Kidney Int. -2016.-Vol. 50(2). - P. 521-525.

Kravchuk I.V., Danilova D.V. Sostoyanie polosti rta u patsientov s chronicheskoy pochechnoy dostatochnostyu - //Ukraїnskiy stomatologichniy almanakh. 2013, No. 5, 98-99.

Kutyrina I.M., Saveleva S.A. Contributing to obesity in kidney damage in patients with type 2 diabetes //Ter. arch. -2018. - No. 6. -B.21-27.

Limeres J. Early tooth loss in end-stage renal disease patients on hemodialysis. / J. Limeres, J.F. Garcez, J.S. [et al.] // Oral. Dis. – 2016. – No. 68 (10). - P. 1125 - 1130.

Meyer T.W., Hostetter T.H. Uremia. // N. Engl. J. Med. 2007. Vol. 357, N 13. P. 1316–1325.

Nurboev.F.E. Djumaev B.Z. The role of genes in the human body in overweight and obesity. Bukhara, New Day Journalin Medicine. 2019. No. 3 / 27.B. 206-211

Spitsyna V.I. Immunnye narusheniya i pathogeneticheskoe obosnovanie ix correctsii u bolnyx kronicheskimi zabolevaniyami slizistoy obolochki polosti rta. – Auto-ref. dis. d.m.n., M., TsNIIS, 2005. – 38 p.

Stepanova E.N., Sinyukhin V.N. drug. Pokaseteli immunitya u bolnykh s terminalnoy stadiei pochechnoi instatochnosti i uremicheskii toxin para-cresol (obzor literatury i sobstvennye issledovaniya) - // Eksperimentalnaya i klinicheskaya Urologiya. 2016, 1, str. 112-119.

Tonelli M., Wiebe N., Culleton B., House A., Rabbat C., Fok M., McAlister F., Garg A.X. Chronic kidney disease and mortality risk: a systematic review. // J. Am. Soc. Nephrol. 2006. Vol. 17, N 7. P. 2034– 2047

Yashchuk E. V. The condition of the patient with terminal stage chronic renal failure does not require dialysis therapy. Abstract dis. k.m.n., St. Petersburg, 2009.