The purpose of this study is to study the features of the course of gout in combination with metabolic syndrome (MS) and to assess the impact of an integrated therapeutic approach on the course of joint syndrome and the dynamics of metabolic disorders. 89 patients with primary chronic gout were examined, verified based on the classification criteria of S. Wallace et al., mainly men – 74 (86.0%), average age 57.35 ± 12.41 years, median duration of the disease at the time of treatment 5.0 (2.0–10.0) years. MS was detected in 63 % of patients with primary chronic gout. The age of gout onset is significantly lower in patients with gout in combination with MS – 47.51 ± 11.03 years (p < 0.001). In the main group, there was a high frequency and duration of gout exacerbations per year (p < 0.01 and p < 0.05, respectively). The maximum serum uric acid (MC) values were detected in the gout group in combination with MS, and have strong direct correlations with the duration of the disease (R = 0.31 at p < 0.05), as well as the frequency exacerbations over the past year (R = 0.37 at p < 0.001). Against the background of allopurinol therapy, all patients showed a decrease in the frequency and duration of exacerbations, in the "MK level control" group, the frequency (median 1.0 [0.0-2.5]) and duration (median 2.5 [0.0–4.0]) of exacerbations were significantly lower compared with the "no MK level control" group (p < 0.01). Among the patients who reached the target values of serum MC in the control period, there was a significantly greater decrease in such indicators as cholesterol, low-density lipoproteins and triglycerides.

Gout, metabolic syndrome, hyperuricemia, highly sensitive C-reactive protein.

Khusainova, M. A., Toirov, D. R., Khaydarov, S. N., & Kamolova, D. D. (2023). MORPHOFUNCTIONAL PARAMETERS OF THE HEART IN WOMEN SUFFERING FROM ESSENTIAL ARTERIAL HYPERTENSION IN POSTMENOPAUSE AND ON THE BACKGROUND OF TREATMENT. Oriental renaissance: Innovative, educational, natural and social sciences, 3(1), 322-330.

Yarmukhamedova, S., Nazarov, F., Mahmudova, X., Vafoeva, N., Bekmuradova, M., Gaffarov, X., ... & Xusainova, M. (2020). Features of diastolic dysfunction of the right ventricle in patients with hypertonic disease. Journal of Advanced Medical and Dental Sciences Research, 8(9), 74-77.

Alisherovna, K. M., Ismatullayevich, M. A., & Nuriddinovna, E. N. (2024). FEATURES OF HEART FAILURE IN PATIENTS WITH CORONARY HEART DISEASE AND THYROTOXICOSIS. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 52-61.

Yarmukhamedova, S., Nazarov, F., Mahmudova, X., Vafoeva, N., Bekmuradova, M., Gafarov, X., ... & Xusainova, M. (2020). Study of indicators of intracardial hemodynamics and structural state of the myocardium in monotherapy of patients with arterial hypertension with moxonidin. Journal of Advanced Medical and Dental Sciences Research, 8(9), 78-81.

Toirov, D. R., & Berdiyev, D. X. (2021). PODAGRA KASALLIGIDA KARDIOGEMODINAMIK BUZILISHLAR O’ZIGA XOSLIGI. Scientific progress, 2(3), 775-784.

Alisherovna, K. M., Habibulloyevna, I. M., & Voxidovna, R. F. (2024). STRUCTURAL AND FUNCTIONAL FEATURES OF THE LEFT VENTRICLE IN PATIENTS WITH HEART FAILUREIN ISCHEMIC HEART DISEASE AND THYROTOXICOSIS. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 71-81.

Rustamovich, T. D., Alisherovna, K. M., Baxtiyorovich, U. J., & Abdurakhmonovich, M. M. (2022). Painless Cardiac Ischemia in Women with Rheumatoid Arthritis. Texas Journal of Medical Science, 13, 95-98.

Rustamovich, T. D., Alisherovna, K. M., Nizamitdinovich, K. S., & Djamshedovna, K. D. (2022). Gastrointestinal Conditions in Rheumatoid Arthritis Patients. Texas Journal of Medical Science, 15, 68-72.

Alisherovna, K. M., Rustamovich, T. D., Baxtiyorovich, U. J., & Sobirovna, S. M. (2022). Diabetes Mellitus and Hyperglycemia in Patients with Rheumatoid Arthritis. Texas Journal of Medical Science, 13, 99-103.

Rustamovich, T. D., Alisherovna, K. M., Djamshedovna, K. D., & Nizamitdinovich, K. S. (2023). Features of the psychoemotional status of patients with rheumatoid arthritis. Miasto Przyszłości, 32, 23-30.

Totlibayevich, Y. S., Alisherovna, K. M., Rustamovich, T. D., & Xudoyberdiyevich, G. X. (2023). Quality of Life in the Pathology of the Cardiovascular System. Miasto Przyszłości, 33, 222-228.

Alisherovna, K. M., Yaxshiboyevich, U. M. R., & Yigitaliyevich, B. A. (2024). EVALUATION OF A NATRIURETIC PEPTIDE TO OPTIMIZE THE MANAGEMENT OF COMORBID PATIENTS WITH THYROTOXICOSIS AND HEART FAILURE. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 62-70.

Nizamitdinovich, K. S., & Alisherovna, K. M. (2022). Quality of Life in Patients with Chronic Heart Failure, After Cardiac Resynchronization Therapy. Texas Journal of Medical Science, 14, 168-173.

Alisherovna, K. M., Rustamovich, T. D., & Baxtiyorovich, U. J. (2022). The Use of Trimetazidine in Patients with Type 2 Diabetes Mellitus Who Have Suffered a Myocardial Infarction. Czech Journal of Multidisciplinary Innovations, 10, 35-41.

Toirov, D. R., & Berdiyev, D. K. (2021). CHARACTERISTICS OF CARDIOHEMODYNAMIC DISORDERS IN GOUT DISEASE. Scientific progress, 2, 775-784.

Alisherovna, K. M., Nizamitdinovich, K. S., Rustamovich, T. D., & Haqnazarovich, K. S. (2022). Mental Status and Quality of Life in Patients With Sinus Node Weakness Syndrome and Chronic Coronary Heart Failure of Ischemic Etiology. Texas Journal of Medical Science, 15, 78-82.

Xudoyberdiyevich, G. X., Alisherovna, K. M., Rustamovich, T. D., & Djamshedovna, K. D. (2023). QUALITY OF LIFE IN PATIENTS WITH GOUT. Spectrum Journal of Innovation, Reforms and Development, 12, 156-164.

Djamshedovna, K. D., Alisherovna, K. M., Xudoyberdiyevich, G. X., & Rustamovich, T. D. (2023). EFFECTIVENESS OF ANTIHYPERTENSIVE THERAPY IN PREGNANT WOMEN. Spectrum Journal of Innovation, Reforms and Development, 12, 137-144.

Alisherovna, K. M., Akramovna, I. K., & Yorkinovna, E. N. (2024). CLINICAL AND MORPHOLOGICAL CRITERIA OF COLITIS IN PATIENTS WITH CHRONIC ISCHEMIC DISEASE OF THE DIGESTIVE SYSTEM. Ta'lim innovatsiyasi va integratsiyasi, 18(6), 6-13.

Alisherovna, K. M., Rustamovich, T. D., Nizamitdinovich, K. S., & Xamroyevna, O. S. (2022). ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH CHRONIC HEART FAILURE WITH PRESERVED CARDIAC OUTPUT. Spectrum Journal of Innovation, Reforms and Development, 9, 467-474.

Rustamovich, T. D., & Khasanovich, B. D. (2022). CHARACTERISTICS OF HEART FUNCTIONAL DISORDERS IN GOUT DISEASE. Galaxy International Interdisciplinary Research Journal, 10(5), 551-558.

Rustamovich, T. D., & Farkhodovna, T. S. (2022). CHARACTERISTICS OF HEART VESSEL INJURY AND JOINT SYNDROME IN GOD DISEASE. Galaxy International Interdisciplinary Research Journal, 10(5), 559-564.

Alisherovna, K. M., Akramovna, I. K., & Baxtiyorovna, O. K. (2024). THE COURSE OF CHRONIC ISCHEMIC PANCREATITIS IN PATIENTS WITH CORONARY HEART DISEASE. Ta'lim innovatsiyasi va integratsiyasi, 18(5), 231-239.

Rustamovich, T. D., Habibovna, Y. T., & Yusufovich, N. F. (2022). COMORBID PASTCHE OF GOUT AND CARDIOVASCULAR DAMAGE. Novateur Publications, (1), 1-102.

Rustamovich, T. D., & Hasanovich, B. D. (2021, February). COMORBID FACTORY OF HEART BLOOD VEHICLES AND METABOLIC SYNDROME IN PATIENTS. In Archive of Conferences (Vol. 14, No. 1, pp. 18-24).

Alisherovna, K. M., Erkinovna, S. D., Yazdonkulovna, X. M., & Zafarovna, C. M. M. (2024). ATRIAL FIBRILLATION IN THYROTOXICOSIS–DETERMINANTS OF DEVELOPMENT AND CONSERVATION. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 103-113.

Uzokov, J. B., Khusainova, M. A., Eshmamatova, F. B., & Mamadiyorova, M. M. (2023). Correction of violations rheology of blood in ischemic heart disease. Science and Education, 4(2), 153-159.

Rustamovich, T. D. (2023). YURAK ISHEMIK KASALLIGI SABABLARI. ENG YAXSHI XIZMATLARI UCHUN, 1(6), 571-573.

Alisherovna, K. M., Akramovna, I. K., & Kairatovna, R. A. (2024). THE EFFECTIVENESS OF TREATMENT OF PATIENTS WITH OSTEOARTHRITIS WITH CARDIOVASCULAR DISORDERS IN METABOLIC SYNDROME. Ta'lim innovatsiyasi va integratsiyasi, 18(5), 223-230.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., & Baxtiyorovich, U. J. (2023). THE EFFECTIVENESS OF THYROSTATICS IN THE TREATMENT OF. Journal of new century innovations, 29(1), 79-88.

Khabibovna, Y. S., Alisherovna, K. M., Nizamitdinovich, K. S., & Totlibayevich, Y. S. (2023). Features of heart failure in patients with thyrotoxicosis. Journal of new century innovations, 29(1), 89-97.

Alisherovna, K. M., Davranovna, M. K., & Erkinovna, K. Z. (2024). CORONARY HEART DISEASE AND OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN. Spectrum Journal of Innovation, Reforms and Development, 26, 40-45.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Nizamitdinovich, K. S., & Abdukadirovna, A. S. (2023). ANTITHROMBOTIC THERAPY IN CARDIOLOGICAL PATIENTS. Journal of new century innovations, 39(1), 169-171.

Khabibovna, Y. S., Alisherovna, K. M., Totlibayevich, Y. S., & Davranovna, M. K. (2023). PAINLESS CARDIAC ISCHEMIA AND RHEUMATOID ARTHRIT. Journal of new century innovations, 29(1), 98-105.

Alisherovna, K. M., Khabibovna, Y. S., Nizamitdinovich, K. S., & Bakhtiyorovich, U. J. (2023). CYSTATIN and KIDNEY FUNCTION. Journal of new century innovations, 38(2), 220-225.

Khabibovna, Y. S., & Buribaevich, N. M. (2020). Study Of Parameters Of Central Hemodynamics In Patients With Chronic Glomerulonephritis. Достижения науки и образования, (13 (67)), 57-59.

Khabibovna, Y. S., Alisherovna, K. M., Nizamitdinovich, K. S., Tashtemirovna, E. M. M., Abdukadirovna, A. S., & Jasurovna, J. S. (2023). DEPRESSION, ANXIETY AND QUALITY OF LIFE IN PATIENTS WITH ATRIAL FIBRILLATION. Journal of new century innovations, 39(1), 185-189.

Alisherovna, K. M., Erkinovna, S. D., Duskobilovich, B. S., & Samandarovich, T. H. (2024). ARTERIAL HYPERTENSION IN THYROTOXICOSIS AND REMODELING OF THE LEFT VENTRICLE OF THE HEART. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 114-121.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Totlibayevich, Y. S., Nizamitdinovich, K. S., & Baxtiyorovich, U. J. (2023). DIAGNOSTIC VALUE OF CYSTATIN C IN PATIENTS WITH HYPERTENSION AND OBESITY. World Bulletin of Public Health, 22, 55-59.

Nizamitdinovich, K. S., Khabibovna, Y. S., Alisherovna, K. M., & Tashtemirovna, E. M. M. (2023). Spinal Injury for Rheumatoid Arthritis. Miasto Przyszłości, 40, 426-432.

Alisherovna, K. M., Mansurovna, M. D., Erkinovna, N. D., Farxodovna, X. R., Toxirovna, M. M., Tolibovna, R. D., & Yorkinovna, E. N. (2024). ARTERIAL HYPERTENSION AND THYROID STATUS IN PATIENTS OF DIFFERENT AGES. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 122-129.

Khabibovna, Y. S., Alisherovna, K. M., Erkinovna, K. Z., & Djamshedovna, K. D. (2023). Gender Characteristics of the Course of Rheumatoid Arthritis. Miasto Przyszłości, 40, 438-442.

Tashtemirovna, E. M. M., Khabibovna, Y. S., Alisherovna, K. M., & Erkinovna, K. Z. (2023). Angiopathy in Rheumatoid Arthritis. Miasto Przyszłości, 40, 418-425.

Davranovna, M. K. D. K., Alisherovna, K. M., & Erkinovna, K. Z. (2024). CARDIAC ARRHYTHMIAS IN PATIENTS WITH RHEUMATOID ARTHRITIS. Spectrum Journal of Innovation, Reforms and Development, 26, 65-71.

Khabibovna, Y. S., & Xudoyberdiyevich, G. X. (2024). THE POSSIBILITIES OF COENZYME Q10 AS PART OF THE COMPLEX THERAPY OF PATIENTS WITH CHRONIC HEART FAILURE. Spectrum Journal of Innovation, Reforms and Development, 25, 116-123.

Yarmukhamedova, S. K., Alisherovna, K. M., Tashtemirovna, E. M. M., & Nizamitdinovich, K. S. (2023). The Effectiveness of Trimetazidine in Arrhythmias. Miasto Przyszłości, 33, 215-221.

Alisherovna, K. M., Nizamitdinovich, K. S., & Erkinovna, K. Z. (2024). THE EFFECTIVENESS OF BISOPROLOL AND METFORMIN IN ARTERIAL HYPERTENSION AND METABOLIC SYNDROME. Spectrum Journal of Innovation, Reforms and Development, 26, 106-113.

Akramovna, I. K., & Alisherovna, K. M. (2024). CAUSES OF ARRHYTHMIA DURING PREGNANCY. Journal of new century innovations, 45(3), 34-41

Yarmukhamedova, S. K., & Gafforov, X. X. (2024). Indicators of daily blood pressure monitoring in patients with osteoarthritis with cardiovascular disorders in case of metabolic syndrome. Science and Education, 5(4), 50-55.

Erkinovna, K. Z., Alisherovna, K. M., & Davranovna, M. K. (2024). ARTERIAL HYPERTENSION AND ARRHYTHMIA. Spectrum Journal of Innovation, Reforms and Development, 26, 72-78.

Nizamitdinovich, K. S., Alisherovna, K. M., & Erkinovna, K. Z. (2024). ASSESSMENT OF THE RISK OF DEVELOPING DIABETES MELLITUS FOR MEN. Spectrum Journal of Innovation, Reforms and Development, 26, 114-123.