Goal. To evaluate the dynamics of clinical symptoms of rheumatoid arthritis (RA) and the activity index under careful control in routine clinical practice.

Material and methods. 112 patients with a reliable (according to the criteria of the ACR) diagnosis of RA were observed (88 women and 24 men, average age 37.8±1.9 years). The patients were divided into 2 groups: Group I was observed for 2 years by a rheumatologist in real clinical practice, 1 time every 3-4 months, group II was under the careful supervision of a rheumatologist-researcher (control of NPV, BBS, NEO, VAS pain, ESR level, counting DAS 28 and the functional index according to HAQ) 1 time per month. The reliability of the differences between the groups was assessed using the t-test Student (significant difference at p<0.05).

Results. In group I, 32.8% of patients achieved acceptable activity (<grade II) of RA within 2 years. Remission was registered in 8.6% of cases. Functional activity according to HAQ did not reach the target level (after 12 months — 1.8±0.4; after 24 months — 1,7 ± 0,8). In group II (n=54), tight control, remission was observed in 47 patients (87%): "induced" in 17 cases (31.5%) and "remission during therapy" — in 30 patients (55.6%). The rate of decrease in all clinical parameters of RA is significantly higher in group II. The changes were noted already by the 3rd month, a significant improvement was achieved by the 6th month (p<0.05), and by the 12th and 24th months this difference is obvious (p<0.01 and p<0.001).

Conclusion. Thus, with careful monitoring, there is a great opportunity for timely and adequate correction of treatment under the control of DAS 28 and HAQ, remission or decrease in RA activity is achieved faster.

Rheumatoid arthritis, RA activity index, quality of life, remission, careful monitoring.

Khusainova, M. A., Toirov, D. R., Khaydarov, S. N., & Kamolova, D. D. (2023). MORPHOFUNCTIONAL PARAMETERS OF THE HEART IN WOMEN SUFFERING FROM ESSENTIAL ARTERIAL HYPERTENSION IN POSTMENOPAUSE AND ON THE BACKGROUND OF TREATMENT. Oriental renaissance: Innovative, educational, natural and social sciences, 3(1), 322-330.

Yarmukhamedova, S., Nazarov, F., Mahmudova, X., Vafoeva, N., Bekmuradova, M., Gaffarov, X., ... & Xusainova, M. (2020). Features of diastolic dysfunction of the right ventricle in patients with hypertonic disease. Journal of Advanced Medical and Dental Sciences Research, 8(9), 74-77.

Alisherovna, K. M., Ismatullayevich, M. A., & Nuriddinovna, E. N. (2024). FEATURES OF HEART FAILURE IN PATIENTS WITH CORONARY HEART DISEASE AND THYROTOXICOSIS. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 52-61.

Yarmukhamedova, S., Nazarov, F., Mahmudova, X., Vafoeva, N., Bekmuradova, M., Gafarov, X., ... & Xusainova, M. (2020). Study of indicators of intracardial hemodynamics and structural state of the myocardium in monotherapy of patients with arterial hypertension with moxonidin. Journal of Advanced Medical and Dental Sciences Research, 8(9), 78-81.

Toirov, D. R., & Berdiyev, D. X. (2021). PODAGRA KASALLIGIDA KARDIOGEMODINAMIK BUZILISHLAR O’ZIGA XOSLIGI. Scientific progress, 2(3), 775-784.

Alisherovna, K. M., Habibulloyevna, I. M., & Voxidovna, R. F. (2024). STRUCTURAL AND FUNCTIONAL FEATURES OF THE LEFT VENTRICLE IN PATIENTS WITH HEART FAILUREIN ISCHEMIC HEART DISEASE AND THYROTOXICOSIS. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 71-81.

Rustamovich, T. D., Alisherovna, K. M., Baxtiyorovich, U. J., & Abdurakhmonovich, M. M. (2022). Painless Cardiac Ischemia in Women with Rheumatoid Arthritis. Texas Journal of Medical Science, 13, 95-98.

Rustamovich, T. D., Alisherovna, K. M., Nizamitdinovich, K. S., & Djamshedovna, K. D. (2022). Gastrointestinal Conditions in Rheumatoid Arthritis Patients. Texas Journal of Medical Science, 15, 68-72.

Alisherovna, K. M., Rustamovich, T. D., Baxtiyorovich, U. J., & Sobirovna, S. M. (2022). Diabetes Mellitus and Hyperglycemia in Patients with Rheumatoid Arthritis. Texas Journal of Medical Science, 13, 99-103.

Rustamovich, T. D., Alisherovna, K. M., Djamshedovna, K. D., & Nizamitdinovich, K. S. (2023). Features of the psychoemotional status of patients with rheumatoid arthritis. Miasto Przyszłości, 32, 23-30.

Alisherovna, K. M., Erkinovna, S. D., Yazdonkulovna, X. M., & Zafarovna, C. M. M. (2024). ATRIAL FIBRILLATION IN THYROTOXICOSIS–DETERMINANTS OF DEVELOPMENT AND CONSERVATION. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 103-113.

Totlibayevich, Y. S., Alisherovna, K. M., Rustamovich, T. D., & Xudoyberdiyevich, G. X. (2023). Quality of Life in the Pathology of the Cardiovascular System. Miasto Przyszłości, 33, 222-228.

Nizamitdinovich, K. S., & Alisherovna, K. M. (2022). Quality of Life in Patients with Chronic Heart Failure, After Cardiac Resynchronization Therapy. Texas Journal of Medical Science, 14, 168-173.

Alisherovna, K. M., Rustamovich, T. D., & Baxtiyorovich, U. J. (2022). The Use of Trimetazidine in Patients with Type 2 Diabetes Mellitus Who Have Suffered a Myocardial Infarction. Czech Journal of Multidisciplinary Innovations, 10, 35-41.

Toirov, D. R., & Berdiyev, D. K. (2021). CHARACTERISTICS OF CARDIOHEMODYNAMIC DISORDERS IN GOUT DISEASE. Scientific progress, 2, 775-784.

Alisherovna, K. M., Nizamitdinovich, K. S., Rustamovich, T. D., & Haqnazarovich, K. S. (2022). Mental Status and Quality of Life in Patients With Sinus Node Weakness Syndrome and Chronic Coronary Heart Failure of Ischemic Etiology. Texas Journal of Medical Science, 15, 78-82.

Xudoyberdiyevich, G. X., Alisherovna, K. M., Rustamovich, T. D., & Djamshedovna, K. D. (2023). QUALITY OF LIFE IN PATIENTS WITH GOUT. Spectrum Journal of Innovation, Reforms and Development, 12, 156-164.

Djamshedovna, K. D., Alisherovna, K. M., Xudoyberdiyevich, G. X., & Rustamovich, T. D. (2023). EFFECTIVENESS OF ANTIHYPERTENSIVE THERAPY IN PREGNANT WOMEN. Spectrum Journal of Innovation, Reforms and Development, 12, 137-144.

Alisherovna, K. M., Rustamovich, T. D., Nizamitdinovich, K. S., & Xamroyevna, O. S. (2022). ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH CHRONIC HEART FAILURE WITH PRESERVED CARDIAC OUTPUT. Spectrum Journal of Innovation, Reforms and Development, 9, 467-474.

Rustamovich, T. D., & Khasanovich, B. D. (2022). CHARACTERISTICS OF HEART FUNCTIONAL DISORDERS IN GOUT DISEASE. Galaxy International Interdisciplinary Research Journal, 10(5), 551-558.

Rustamovich, T. D., & Farkhodovna, T. S. (2022). CHARACTERISTICS OF HEART VESSEL INJURY AND JOINT SYNDROME IN GOD DISEASE. Galaxy International Interdisciplinary Research Journal, 10(5), 559-564.

Alisherovna, K. M., Yaxshiboyevich, U. M. R., & Yigitaliyevich, B. A. (2024). EVALUATION OF A NATRIURETIC PEPTIDE TO OPTIMIZE THE MANAGEMENT OF COMORBID PATIENTS WITH THYROTOXICOSIS AND HEART FAILURE. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 62-70.

Rustamovich, T. D., Habibovna, Y. T., & Yusufovich, N. F. (2022). COMORBID PASTCHE OF GOUT AND CARDIOVASCULAR DAMAGE. Novateur Publications, (1), 1-102.

Rustamovich, T. D., & Hasanovich, B. D. (2021, February). COMORBID FACTORY OF HEART BLOOD VEHICLES AND METABOLIC SYNDROME IN PATIENTS. In Archive of Conferences (Vol. 14, No. 1, pp. 18-24).

Alisherovna, K. M., Erkinovna, S. D., Duskobilovich, B. S., & Samandarovich, T. H. (2024). ARTERIAL HYPERTENSION IN THYROTOXICOSIS AND REMODELING OF THE LEFT VENTRICLE OF THE HEART. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 114-121.

Rustamovich, T. D. (2023). YURAK ISHEMIK KASALLIGI SABABLARI. ENG YAXSHI XIZMATLARI UCHUN, 1(6), 571-573.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., & Baxtiyorovich, U. J. (2023). THE EFFECTIVENESS OF THYROSTATICS IN THE TREATMENT OF. Journal of new century innovations, 29(1), 79-88.

Alisherovna, K. M., Akramovna, I. K., & Yorkinovna, E. N. (2024). CLINICAL AND MORPHOLOGICAL CRITERIA OF COLITIS IN PATIENTS WITH CHRONIC ISCHEMIC DISEASE OF THE DIGESTIVE SYSTEM. Ta'lim innovatsiyasi va integratsiyasi, 18(6), 6-13.

Khabibovna, Y. S., Alisherovna, K. M., Nizamitdinovich, K. S., & Totlibayevich, Y. S. (2023). Features of heart failure in patients with thyrotoxicosis. Journal of new century innovations, 29(1), 89-97.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Nizamitdinovich, K. S., & Abdukadirovna, A. S. (2023). ANTITHROMBOTIC THERAPY IN CARDIOLOGICAL PATIENTS. Journal of new century innovations, 39(1), 169-171.

Alisherovna, K. M., Akramovna, I. K., & Baxtiyorovna, O. K. (2024). THE COURSE OF CHRONIC ISCHEMIC PANCREATITIS IN PATIENTS WITH CORONARY HEART DISEASE. Ta'lim innovatsiyasi va integratsiyasi, 18(5), 231-239.

Khabibovna, Y. S., Alisherovna, K. M., Totlibayevich, Y. S., & Davranovna, M. K. (2023). PAINLESS CARDIAC ISCHEMIA AND RHEUMATOID ARTHRIT. Journal of new century innovations, 29(1), 98-105.

Alisherovna, K. M., Khabibovna, Y. S., Nizamitdinovich, K. S., & Bakhtiyorovich, U. J. (2023). CYSTATIN and KIDNEY FUNCTION. Journal of new century innovations, 38(2), 220-225.

Khabibovna, Y. S., & Buribaevich, N. M. (2020). Study Of Parameters Of Central Hemodynamics In Patients With Chronic Glomerulonephritis. Достижения науки и образования, (13 (67)), 57-59.

Khabibovna, Y. S., Alisherovna, K. M., Nizamitdinovich, K. S., Tashtemirovna, E. M. M., Abdukadirovna, A. S., & Jasurovna, J. S. (2023). DEPRESSION, ANXIETY AND QUALITY OF LIFE IN PATIENTS WITH ATRIAL FIBRILLATION. Journal of new century innovations, 39(1), 185-189.

Alisherovna, K. M., Akramovna, I. K., & Kairatovna, R. A. (2024). THE EFFECTIVENESS OF TREATMENT OF PATIENTS WITH OSTEOARTHRITIS WITH CARDIOVASCULAR DISORDERS IN METABOLIC SYNDROME. Ta'lim innovatsiyasi va integratsiyasi, 18(5), 223-230.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Totlibayevich, Y. S., Nizamitdinovich, K. S., & Baxtiyorovich, U. J. (2023). DIAGNOSTIC VALUE OF CYSTATIN C IN PATIENTS WITH HYPERTENSION AND OBESITY. World Bulletin of Public Health, 22, 55-59.

Nizamitdinovich, K. S., Khabibovna, Y. S., Alisherovna, K. M., & Tashtemirovna, E. M. M. (2023). Spinal Injury for Rheumatoid Arthritis. Miasto Przyszłości, 40, 426-432.

Alisherovna, K. M., Davranovna, M. K., & Erkinovna, K. Z. (2024). CORONARY HEART DISEASE AND OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN. Spectrum Journal of Innovation, Reforms and Development, 26, 40-45.

Khabibovna, Y. S., Alisherovna, K. M., Erkinovna, K. Z., & Djamshedovna, K. D. (2023). Gender Characteristics of the Course of Rheumatoid Arthritis. Miasto Przyszłości, 40, 438-442.

Tashtemirovna, E. M. M., Khabibovna, Y. S., Alisherovna, K. M., & Erkinovna, K. Z. (2023). Angiopathy in Rheumatoid Arthritis. Miasto Przyszłości, 40, 418-425.

Alisherovna, K. M., Mansurovna, M. D., Erkinovna, N. D., Farxodovna, X. R., Toxirovna, M. M., Tolibovna, R. D., & Yorkinovna, E. N. (2024). ARTERIAL HYPERTENSION AND THYROID STATUS IN PATIENTS OF DIFFERENT AGES. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 122-129.

Khabibovna, Y. S., & Alisherovna, K. M. (2024). STRESS TESTING IN PATIENTS WITH CORONARY HEART DISEASE. Journal of new century innovations, 45(3), 28-33.

Khabibovna, Y. S., & Xudoyberdiyevich, G. X. (2024). THE POSSIBILITIES OF COENZYME Q10 AS PART OF THE COMPLEX THERAPY OF PATIENTS WITH CHRONIC HEART FAILURE. Spectrum Journal of Innovation, Reforms and Development, 25, 116-123.

Davranovna, M. K. D. K., Alisherovna, K. M., & Erkinovna, K. Z. (2024). CARDIAC ARRHYTHMIAS IN PATIENTS WITH RHEUMATOID ARTHRITIS. Spectrum Journal of Innovation, Reforms and Development, 26, 65-71.

Erkinovna, K. Z., Alisherovna, K. M., & Davranovna, M. K. (2024). ARTERIAL HYPERTENSION AND ARRHYTHMIA. Spectrum Journal of Innovation, Reforms and Development, 26, 72-78.

Nizamitdinovich, K. S., Alisherovna, K. M., & Erkinovna, K. Z. (2024). ASSESSMENT OF THE RISK OF DEVELOPING DIABETES MELLITUS FOR MEN. Spectrum Journal of Innovation, Reforms and Development, 26, 114-123.

Alisherovna, K. M., Nizamitdinovich, K. S., & Erkinovna, K. Z. (2024). THE EFFECTIVENESS OF BISOPROLOL AND METFORMIN IN ARTERIAL HYPERTENSION AND METABOLIC SYNDROME. Spectrum Journal of Innovation, Reforms and Development, 26, 106-113.

Akramovna, I. K., & Alisherovna, K. M. (2024). CAUSES OF ARRHYTHMIA DURING PREGNANCY. Journal of new century innovations, 45(3), 34-41.

Yarmukhamedova, S. K., Alisherovna, K. M., Tashtemirovna, E. M. M., & Nizamitdinovich, K. S. (2023). The Effectiveness of Trimetazidine in Arrhythmias. Miasto Przyszłości, 33, 215-221.

Yarmukhamedova, S. K., & Gafforov, X. X. (2024). Indicators of daily blood pressure monitoring in patients with osteoarthritis with cardiovascular disorders in case of metabolic syndrome. Science and Education, 5(4), 50-55.