A comparative assessment of the therapeutic effects of sulfasalazine (C), methotrexate (MT) and leflunomide (LV) was performed in 151 patients with early rheumatoid arthritis (RRA) during 12 months of follow-up. SS therapy in RPA was not effective enough. MT therapy and LF significantly reduced clinical and laboratory activity and improved the quality of life of RA patients after 12 months months of observation. In 16 patients with moderate and high degrees of disease activity, despite previous therapy with C, MT and LF, combination therapy with infliximab and MT for 24 weeks resulted in to a significant improvement in the clinical course of the disease and the quality of life. A direct correlation was noted between the functional index of the NAI health assessment and the number of RA patients with anxiety and depressive disorders.

Quality of life, rheumatoid arthritis, methotrexate, early rheumatoid arthritis, infliximab, sulfasalazine, anxiety and depressive disorders.

Uzokov, J. B., Khusainova, M. A., Eshmamatova, F. B., & Mamadiyorova, M. M. (2023). Correction of violations rheology of blood in ischemic heart disease. Science and Education, 4(2), 153-159.

Khaydarov, S. N., Khusainova, M. A., Uzokov, J. B., & Makhmudova, K. D. (2023). Heart failure and the risk of hypoglycemia. Science and Education, 4(5), 222-231.

Khusainova, M. A., Khaydarov, S. N., Uzokov, J. B., & Karabayeva, G. K. (2023). KIDNEY CONDITION IN PATIENTS WITH CHRONIC HEART FAILURE. Oriental renaissance: Innovative, educational, natural and social sciences, 3(2), 102-112.

Uzokov, J. B., Khusainova, M. A., Bekmuradova, M. S., & Makhmudova, K. D. (2023). Dynamics of quality of life indicators during personalized rehabilitation of patients with rheumatoid arthritis with arterial hypertension. Science and Education, 4(5), 196-204.

Khusainova, M. A., Bekmuradova, M. S., Makhmudova, K. D., & Uzokov, J. B. (2023). Echocardiographic changes of the left ventricle in bronchial asthma. Science and Education, 4(5), 214-221.

Khusainova, M. A., Khaydarov, S. N., Uzokov, J. B., & Shonazarova, N. K. (2023). QUALITY OF LIFE IN PATIENTS WITH CHOLELITHIASIS IN THE LONG-TERM PERIOD AFTER CHOLECYSTECTOMY. Oriental renaissance: Innovative, educational, natural and social sciences, 3(2), 231-239.

Khusainova, M. A., Gafforov, K. K., Uzokov, J. B., & Tairova, Z. K. (2023). THE CHANGE IN THE QT INTERVAL IS A MARKER OF THE SEVERITY OF LIVER CIRRHOSIS. Oriental renaissance: Innovative, educational, natural and social sciences, 3(2), 94-101.

Khusainova, M. A., Gafforov, K. K., Uzokov, J. B., & Tairova, Z. K. (2023). THE CHANGE IN THE QT INTERVAL IS A MARKER OF THE SEVERITY OF LIVER CIRRHOSIS. Oriental renaissance: Innovative, educational, natural and social sciences, 3(2), 94-101.

Rustamovich, T. D., Alisherovna, K. M., Baxtiyorovich, U. J., & Abdurakhmonovich, M. M. (2022). Painless Cardiac Ischemia in Women with Rheumatoid Arthritis. Texas Journal of Medical Science, 13, 95-98.

Alisherovna, K. M., Rustamovich, T. D., Baxtiyorovich, U. J., & Sobirovna, S. M. (2022). Diabetes Mellitus and Hyperglycemia in Patients with Rheumatoid Arthritis. Texas Journal of Medical Science, 13, 99-103.

Alisherovna, K. M., Rustamovich, T. D., & Baxtiyorovich, U. J. (2022). The Use of Trimetazidine in Patients with Type 2 Diabetes Mellitus Who Have Suffered a Myocardial Infarction. Czech Journal of Multidisciplinary Innovations, 10, 35-41.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., & Baxtiyorovich, U. J. (2023). THE EFFECTIVENESS OF THYROSTATICS IN THE TREATMENT OF. Journal of new century innovations, 29(1), 79-88.

Alisherovna, K. M., Akramovna, I. K., Bakhtiyorovich, U. J., Nizamitdinovich, K. S., Jasurovna, J. S., Kairatovna, R. A., & Abdukholikovna, E. S. (2023). Exacerbations of chronic obstructive pulmonary disease and coronary atherosclerosis. Journal of new century innovations, 39(1), 176-178.

Baxtiyorovich, U. J., Alisherovna, K. M., & Mamasoliyevna, D. N. (2023). Features of cognitive impairment in patients with chronic kidney disease at predialysis stages. World Bulletin of Public Health, 22, 49-54.

Alisherovna, K. M., Khabibovna, Y. S., Nizamitdinovich, K. S., & Bakhtiyorovich, U. J. (2023). CYSTATIN and KIDNEY FUNCTION. Journal of new century innovations, 38(2), 220-225.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Totlibayevich, Y. S., Nizamitdinovich, K. S., & Baxtiyorovich, U. J. (2023). DIAGNOSTIC VALUE OF CYSTATIN C IN PATIENTS WITH HYPERTENSION AND OBESITY. World Bulletin of Public Health, 22, 55-59.

Davranovna, M. K. D. K., Alisherovna, K. M., & Erkinovna, K. Z. (2024). CARDIAC ARRHYTHMIAS IN PATIENTS WITH RHEUMATOID ARTHRITIS. Spectrum Journal of Innovation, Reforms and Development, 26, 65-71.

Nizamitdinovich, K. S., Alisherovna, K. M., & Erkinovna, K. Z. (2024). ASSESSMENT OF THE RISK OF DEVELOPING DIABETES MELLITUS FOR MEN. Spectrum Journal of Innovation, Reforms and Development, 26, 114-123.

Alisherovna, K. M., Nizamitdinovich, K. S., & Erkinovna, K. Z. (2024). THE EFFECTIVENESS OF BISOPROLOL AND METFORMIN IN ARTERIAL HYPERTENSION AND METABOLIC SYNDROME. Spectrum Journal of Innovation, Reforms and Development, 26, 106-113.

Erkinovna, K. Z., Alisherovna, K. M., & Davranovna, M. K. (2024). ARTERIAL HYPERTENSION AND ARRHYTHMIA. Spectrum Journal of Innovation, Reforms and Development, 26, 72-78.

Akramovna, I. K., & Alisherovna, K. M. (2024). CAUSES OF ARRHYTHMIA DURING PREGNANCY. Journal of new century innovations, 45(3), 34-41.

Bakhtiyorovich, U. J. (2024). METABOLISM REGULATOR IN PATIENTS WITH CHRONIC HEART FAILURE AND ANEMIA OF CHRONIC DISEASES. Journal of new century innovations, 45(3), 3-12.

Bakhtiyorovich, U. J. (2024). FEATURES OF THE COGNITIVE STATUS IN WOMEN WITH IRON DEFICIENCY ANEMIA. Spectrum Journal of Innovation, Reforms and Development, 24, 27-32.

Alisherovna, K. M., Mansurovna, M. D., Erkinovna, N. D., Farxodovna, X. R., Toxirovna, M. M., Tolibovna, R. D., & Yorkinovna, E. N. (2024). ARTERIAL HYPERTENSION AND THYROID STATUS IN PATIENTS OF DIFFERENT AGES. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 122-129.

Erkinovna, K. Z., Alisherovna, K. M., Bakhtiyorovich, U. J., & Djamshedovna, K. D. (2023). METABOLIC SYNDROME IN RHEUMATOID ARTHRITIS. Journal of new century innovations, 38(2), 203-211.

Yarmukhamedova, S., Nazarov, F., Mahmudova, X., Vafoeva, N., Bekmuradova, M., Gaffarov, X., ... & Xusainova, M. (2020). Features of diastolic dysfunction of the right ventricle in patients with hypertonic disease. Journal of Advanced Medical and Dental Sciences Research, 8(9), 74-77.

Alisherovna, K. M., Davranovna, M. K., & Erkinovna, K. Z. (2024). CORONARY HEART DISEASE AND OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN. Spectrum Journal of Innovation, Reforms and Development, 26, 40-45.

Xaydarov, S. N., & Normatov, M. B. (2021). DETERMINATION OF IRON DEFICIENCY ANEMIA AT THE PREGNANCY PERIOD. Scientific progress, 2(4), 325-327.

Yarmukhamedova, S., Nazarov, F., Mahmudova, X., Vafoeva, N., Bekmuradova, M., Gafarov, X., ... & Xusainova, M. (2020). Study of indicators of intracardial hemodynamics and structural state of the myocardium in monotherapy of patients with arterial hypertension with moxonidin. Journal of Advanced Medical and Dental Sciences Research, 8(9), 78-81.

Alisherovna, K. M., Akramovna, I. K., & Kairatovna, R. A. (2024). THE EFFECTIVENESS OF TREATMENT OF PATIENTS WITH OSTEOARTHRITIS WITH CARDIOVASCULAR DISORDERS IN METABOLIC SYNDROME. Ta'lim innovatsiyasi va integratsiyasi, 18(5), 223-230.

Normatov, M. B. (2023). Features of management of patients with chronic heart failure and diabetes mellitus. Science and Education, 4(5), 251-259.

Khabibovna, Y. S., & Buribaevich, N. M. (2020). Study Of Parameters Of Central Hemodynamics In Patients With Chronic Glomerulonephritis. Достижения науки и образования, (13 (67)), 57-59.

Buribayevich, N. M. (2022). Treatment of Chronic Heart Failure in Patients with Type 2 Diabetes Mellitus. Central Asian Journal of Medical and Natural Science, 3(1), 183-186.

Alisherovna, K. M., Akramovna, I. K., & Baxtiyorovna, O. K. (2024). THE COURSE OF CHRONIC ISCHEMIC PANCREATITIS IN PATIENTS WITH CORONARY HEART DISEASE. Ta'lim innovatsiyasi va integratsiyasi, 18(5), 231-239.

Buribayevich, N. M. (2022). DIASTOLIC DYSFUNCTION AND REMODELING LEFT VENTRICLE DEPENDING ON THE CONTROL GLYCEMIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. Spectrum Journal of Innovation, Reforms and Development, 7, 96-100.

Buribayevich, N. M. (2022). Index of Functional Changes in the Assessment Adaptive State of Comorbid Patients Treated with Trimetazidine. Czech Journal of Multidisciplinary Innovations, 10, 42-48.

Alisherovna, K. M., Akramovna, I. K., & Yorkinovna, E. N. (2024). CLINICAL AND MORPHOLOGICAL CRITERIA OF COLITIS IN PATIENTS WITH CHRONIC ISCHEMIC DISEASE OF THE DIGESTIVE SYSTEM. Ta'lim innovatsiyasi va integratsiyasi, 18(6), 6-13.

Buribayevich, N. M. (2022). Applications the drug nicomex at treatment of patients with chronic heart failure and type 2 diabetes mellitus.

Khabibovna, Y. S., Alisherovna, K. M., Nizamitdinovich, K. S., & Totlibayevich, Y. S. (2023). Features of heart failure in patients with thyrotoxicosis. Journal of new century innovations, 29(1), 89-97.

Alisherovna, K. M., Erkinovna, S. D., Duskobilovich, B. S., & Samandarovich, T. H. (2024). ARTERIAL HYPERTENSION IN THYROTOXICOSIS AND REMODELING OF THE LEFT VENTRICLE OF THE HEART. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 114-121.

Khabibovna, Y. S., Alisherovna, K. M., Tashtemirovna, E. M. M., Nizamitdinovich, K. S., & Abdukadirovna, A. S. (2023). ANTITHROMBOTIC THERAPY IN CARDIOLOGICAL PATIENTS. Journal of new century innovations, 39(1), 169-171.

Khabibovna, Y. S., Alisherovna, K. M., Totlibayevich, Y. S., & Davranovna, M. K. (2023). PAINLESS CARDIAC ISCHEMIA AND RHEUMATOID ARTHRIT. Journal of new century innovations, 29(1), 98-105.

Alisherovna, K. M., Yaxshiboyevich, U. M. R., & Yigitaliyevich, B. A. (2024). EVALUATION OF A NATRIURETIC PEPTIDE TO OPTIMIZE THE MANAGEMENT OF COMORBID PATIENTS WITH THYROTOXICOSIS AND HEART FAILURE. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 62-70.

Khabibovna, Y. S., Alisherovna, K. M., Nizamitdinovich, K. S., Tashtemirovna, E. M. M., Abdukadirovna, A. S., & Jasurovna, J. S. (2023). DEPRESSION, ANXIETY AND QUALITY OF LIFE IN PATIENTS WITH ATRIAL FIBRILLATION. Journal of new century innovations, 39(1), 185-189.

Nizamitdinovich, K. S., Khabibovna, Y. S., Alisherovna, K. M., & Tashtemirovna, E. M. M. (2023). Spinal Injury for Rheumatoid Arthritis. Miasto Przyszłości, 40, 426-432.

Alisherovna, K. M., Erkinovna, S. D., Yazdonkulovna, X. M., & Zafarovna, C. M. M. (2024). ATRIAL FIBRILLATION IN THYROTOXICOSIS–DETERMINANTS OF DEVELOPMENT AND CONSERVATION. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 103-113.

Khabibovna, Y. S., Alisherovna, K. M., Erkinovna, K. Z., & Djamshedovna, K. D. (2023). Gender Characteristics of the Course of Rheumatoid Arthritis. Miasto Przyszłości, 40, 438-442.

Tashtemirovna, E. M. M., Khabibovna, Y. S., Alisherovna, K. M., & Erkinovna, K. Z. (2023). Angiopathy in Rheumatoid Arthritis. Miasto Przyszłości, 40, 418-425.

Alisherovna, K. M., Habibulloyevna, I. M., & Voxidovna, R. F. (2024). STRUCTURAL AND FUNCTIONAL FEATURES OF THE LEFT VENTRICLE IN PATIENTS WITH HEART FAILUREIN ISCHEMIC HEART DISEASE AND THYROTOXICOSIS. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 71-81.

Khabibovna, Y. S., & Alisherovna, K. M. (2024). STRESS TESTING IN PATIENTS WITH CORONARY HEART DISEASE. Journal of new century innovations, 45(3), 28-33.

Khabibovna, Y. S., & Xudoyberdiyevich, G. X. (2024). THE POSSIBILITIES OF COENZYME Q10 AS PART OF THE COMPLEX THERAPY OF PATIENTS WITH CHRONIC HEART FAILURE. Spectrum Journal of Innovation, Reforms and Development, 25, 116-123.

Alisherovna, K. M., Ismatullayevich, M. A., & Nuriddinovna, E. N. (2024). FEATURES OF HEART FAILURE IN PATIENTS WITH CORONARY HEART DISEASE AND THYROTOXICOSIS. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 52-61.

Yarmukhamedova, S. K., Alisherovna, K. M., Tashtemirovna, E. M. M., & Nizamitdinovich, K. S. (2023). The Effectiveness of Trimetazidine in Arrhythmias. Miasto Przyszłości, 33, 215-221.

Yarmukhamedova, S. K., & Gafforov, X. X. (2024). Indicators of daily blood pressure monitoring in patients with osteoarthritis with cardiovascular disorders in case of metabolic syndrome. Science and Education, 5(4), 50-55.