The aim is to determine the frequency of autoantibody detection in a cohort of Uzbek patients with systemic scleroderma (SSD), to study the clinical associations of the detected antibodies.

Material and methods. From 2021 to 2024. The study included 60 patients (12 men and 48 women) who met the criteria of the American College of Rheumatology/European Antirheumatic League (ACR/EULAR) SSDs. All patients underwent an immunological examination, including determination of antinuclear antibodies, antibodies to topoisomerase I (anti-Scl-70), to centromeres (ACA), to ribonucleoproteins (anti-UI-RNP), to ribonucleoprotease III (anti-RNCP III).

Results and discussion. The vast majority of patients were female, middle-aged, with a moderate duration of the disease. Patients with a limited form prevailed (55.3%), 37.4% patients had diffuse, 5.9% – cross (overlap syndrome); <1% - visceral and juvenile forms of SSD. The vast majority (83.8%) of patients had an antinuclear factor. The most common of the SSD-associated antibodies (approximately half of the patients) were antiScl-70. ACA occurred in only 9 (14.6%) patients. A combination of ACA positivity and anti-Scl-70 was observed in three patients with limited SSD, including one with an early form of the disease. 5 patients were positive for anti-UI-RNP. Among them, patients with limited and cross-sectional forms of SSD prevailed. Anti-RNCP III was detected in 5.5% of cases, mainly in the group patients with a limited form of SSD; in one case, they were detected in a patient with diffuse skin lesions and severe interstitial lung damage. Kidney damage was not observed in this group of patients.

Conclusion. The peculiarities of the Russian cohort are the predominance of the limited form of SSD and the frequent detection of anti-Scl-70 in both diffuse and limited forms of SSD; the absence of correlations of anti-Scl-70 with rapid progression of the pathological process, kidney pathology.

Systemic scleroderma; limited form; diffuse form; autoantibodies; associations.

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