Hemorrhagic vasculitis (Henoch-Schönlein purpura) is the most common manifestation of inflammation of the small vessels and may result in severe complications if nephropathy develops. The aim of this study is to investigate the correlation between immune-hematological markers and the development of nephropathy. Literature review demonstrates that IgA immunoglobulins, the complement factors, cytokine levels, and alterations in platelet function are determinants of nephropathy development. Results indicate that deposition of IgA deposits in glomeruli, decreased C3 and C4 complement levels, increased levels of IL-6 and TNF-α cytokines, and platelet function disorders correlate directly with nephropathy development.

hemorrhagic vasculitis, nephropathy, immunoglobulin A, complement system, cytokines, platelet activity

Jennette, J.C., Falk, R.J., Bacon, P.A., et al. (2013). 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis & Rheumatism, 65(1), 1-11.

Davin, J.C., & Coppo, R. (2014). Henoch-Schönlein purpura nephritis in children. Nature Reviews Nephrology, 10(10), 563-573.

Aminova, G.N., & Rakhimova, N.S. (2020). Clinical and epidemiological characteristics of hemorrhagic vasculitis in children in Uzbekistan. Journal of Pediatric Nephrology, 15(3), 234-240.

Игнатова, М.С., & Вельтищев, Ю.Е. (2019). Иммунопатогенез нефрита при геморрагическом васкулите у детей. Педиатрия, 98(4), 45-52.

Moldoveanu, Z., Wyatt, R.J., Lee, J.Y., et al. (2007). Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Kidney International, 71(11), 1148-1154.

Юсупова, Д.М., & Каримова, З.Х. (2021). Особенности течения пурпуры Шенлейна-Геноха у детей узбекской популяции. Детская нефрология, 25(2), 78-84.

López-Mejías, R., Genre, F., Sevilla-Pérez, B., et al. (2018). Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated systematic review. Autoimmunity Reviews, 17(3), 301-315.

Соколова, Л.В., Петрова, И.А., & Смирнов, А.В. (2018). Роль системы комплемента в развитии нефрита при геморрагическом васкулите. Нефрология, 22(5), 67-74.

Кучеренко, А.Г., Багдасарова, И.В., & Длин, В.В. (2019). Цитокиновый профиль при геморрагическом васкулите с поражением почек у детей. Педиатрическая нефрология, 23(1), 28-35.

Narzullayev, U.N., & Sharipova, M.A. (2022). Hemostatic disorders in children with Henoch-Schönlein purpura nephritis. Central Asian Journal of Pediatrics, 8(2), 145-152.