This study investigates the clinical efficacy of Platelet-Rich Plasma (PRP) therapy in women with diminished ovarian reserve (DOR) and its subsequent impact on in vitro fertilization (IVF) outcomes. Diminished ovarian reserve is a significant factor contributing to infertility, often associated with reduced oocyte quantity and quality, leading to poor response during assisted reproductive technologies. PRP therapy, which involves autologous platelet concentration with growth factors, has emerged as a potential intervention to improve ovarian function and follicular development. The study evaluates changes in ovarian reserve markers, such as anti-Müllerian hormone (AMH), antral follicle count (AFC), and hormonal profiles, as well as IVF outcomes including oocyte retrieval numbers, embryo quality, implantation rates, and clinical pregnancy rates. The findings aim to provide insight into the therapeutic potential of PRP in enhancing fertility outcomes among women with compromised ovarian reserve.

Diminished ovarian reserve (dor), platelet-rich plasma (prp) therapy, ovarian rejuvenation, in vitro fertilization (ivf) outcomes, assisted reproductive technology (art), anti-müllerian hormone (amh), antral follicle count (afc), oocyte quality, embryo development, clinical pregnancy rate, infertility treatment, ovarian function enhancement.

Broekmans, F. J., Kwee, J., Hendriks, D., Mol, B. W., & Lambalk, C. B. (2009). Ovarian aging: Mechanisms and clinical consequences. Endocrine Reviews, 30(5), 465–493. https://doi.org/10.1210/er.2009-0006

Marx, R. E. (2004). Platelet-rich plasma: Evidence to support its use. Journal of Oral and Maxillofacial Surgery, 62(4), 489–496. https://doi.org/10.1016/j.joms.2003.12.003

Pantos, K., Tzioras, P., Koutsilieris, M., & Papadopoulou, C. (2016). Ovarian rejuvenation with platelet-rich plasma: A novel approach to fertility enhancement. Reproductive BioMedicine Online, 32(6), 720–730. https://doi.org/10.1016/j.rbmo.2016.03.010

Sfakianoudis, K., Simopoulou, M., Tsioulou, P., Rapani, A., Giannelou, P., & Pantos, K. (2018). Intra-ovarian platelet-rich plasma administration in women with poor ovarian reserve: A pilot study. Frontiers in Endocrinology, 9, 187. https://doi.org/10.3389/fendo.2018.00187

Cakiroglu, Y., Saltik, A., Yuceturk, A., Karaosmanoglu, O., & Urman, B. (2020). Intra-ovarian platelet-rich plasma injection in IVF cycles: Outcomes and clinical potential. Journal of Assisted Reproduction and Genetics, 37(6), 1413–1422. https://doi.org/10.1007/s10815-020-01800-1

Farimani, M. M., Shahrokhi, S., & Alborzi, S. (2021). Platelet-rich plasma in reproductive medicine: Mechanisms and clinical applications. Reproductive Sciences, 28(8), 2174–2185. https://doi.org/10.1007/s43032-020-00404-9

Sfakianoudis, K., Simopoulou, M., Tsioulou, P., Rapani, A., Giannelou, P., Pantos, K., & Anifandis, G. (2019). The role of platelet-rich plasma in ovarian rejuvenation: Current evidence and future perspectives. Reproductive Biology and Endocrinology, 17(1), 11. https://doi.org/10.1186/s12958-019-0457-0