
THE ROLE OF IMMUNE COMPLEXES IN CHILDREN WITH HEMORRHAGIC VASCULITIS (SCHONLEIN-HENOCH VASCULITIS) AND THEIR RELATIONSHIP WITH CLINICAL FORMS
Nizamutdinov Avazbek Maripdjonovich , Assistant, Departmentof Hospital Pediatrics Andijan State Medical Institute, UzbekistanAbstract
Henoch-Schönlein purpura, now more specifically termed IgA Vasculitis (IgAV), is the most common systemic vasculitis in children. While often a self-limiting disease, it can lead to severe and chronic complications, most notably IgA vasculitis nephritis (IgAV-N), which can progress to end-stage renal disease. The pathogenesis is fundamentally driven by the formation and deposition of IgA-containing immune complexes in the small vessel walls of target organs. Understanding the precise role of these immune complexes—their composition, size, and quantity—and elucidating their relationship with the diverse clinical manifestations (skin, joint, gastrointestinal, and renal) is of critical importance. This knowledge is essential for developing prognostic biomarkers to identify children at high risk for severe complications like nephritis and for designing targeted therapies that go beyond non-specific immunosuppression.
Keywords
IgA vasculitis, Henoch-Schönlein purpura, immune complexes, IgA nephropathy, glomerulonephritis, pediatric vasculitis, pathogenesis.
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