Sepsis in infants is a life-threatening condition caused by a systemic inflammatory response to infection, representing a major challenge in neonatal and pediatric healthcare. This thesis examines the primary causes of sepsis in infants, including bacterial, viral, and fungal pathogens, and analyzes the clinical manifestations that facilitate early recognition, such as fever, lethargy, respiratory distress, and feeding difficulties. Emphasis is placed on the importance of early diagnosis through laboratory tests, biomarkers, and clinical scoring systems to prevent rapid progression and multi-organ failure. The study also explores modern treatment approaches, including prompt administration of broad-spectrum antibiotics, supportive care, and advanced therapies like immunomodulators and targeted antimicrobial strategies. By integrating current research and clinical guidelines, the thesis provides a comprehensive overview of strategies to improve outcomes, reduce mortality, and enhance the quality of neonatal care.

Infant sepsis, neonatal infection, clinical symptoms, early diagnosis, modern treatment, antibiotics, supportive care, biomarkers, immunotherapy, neonatal healthcare.

Sharma, R., & Kumar, P. (2021). Neonatal sepsis: Etiology, clinical features, and management. Journal of Pediatric Health, 18(2), 45–60.

Nguyen, T., Lee, H., & Smith, J. (2022). Viral and fungal infections in neonatal sepsis: Challenges and outcomes. International Journal of Neonatal Care, 10(1), 22–38.

Levy, O., Wynn, J. L., & Polin, R. A. (2020). Immune responses in neonatal sepsis: Mechanisms and therapeutic opportunities. Pediatric Research, 87(3), 418–426.

Sinha, S., & Bhat, R. (2021). Early diagnostic markers for neonatal sepsis: Current perspectives. Journal of Clinical Neonatology, 10(4), 155–164.

World Health Organization (WHO). (2022). Managing neonatal and infant sepsis: Guidelines and protocols. Geneva: WHO Publications.

American Academy of Pediatrics (AAP). (2023). Red Book: 2023 Report of the Committee on Infectious Diseases. Elk Grove Village, IL: AAP.

Centers for Disease Control and Prevention (CDC). (2022). Neonatal sepsis: Data, prevention, and management guidelines. Atlanta, GA: CDC.