
EARLY DIAGNOSIS, PREVENTION OF COMPLICATIONS, LABORATORY INDICATORS, AND TREATMENT OF INTRAUTERINE INFECTIONS IN NEWBORNS
Shaudirbayeva Asem Kambul kizi , Neonatologist, Republican Multidisciplinary Children's Medical Center, Republic of Karakalpakstan, UzbekistanAbstract
Intrauterine infections are a common cause of health problems in newborns. Early diagnosis and treatment are very important to prevent complications. This study looked at 120 newborns with suspected infections. Clinical examination, blood tests (CRP, procalcitonin, IL-6), serological tests, and PCR were used to identify infections. Treatment included antibiotics, antiviral therapy, and supportive care.
Out of 120 newborns, 72 had confirmed infections. Higher levels of CRP, procalcitonin, and IL-6 were found in infected babies. PCR detected TORCH pathogens in most cases, with CMV being the most common. Early treatment reduced serious complications and improved recovery.
Early detection and proper treatment of intrauterine infections help improve the health and survival of newborns.
Keywords
Intrauterine infections, Newborns, Early diagnosis, TORCH, Blood tests, Antibiotic therapy, Antiviral therapyIntroduction
References
Goldenberg R.L., Culhane J.F. Infection as a cause of preterm birth. Clin Perinatol. 2003;30(4):677–700.
Chiesa C., Pacifico L., Osborn J.F. Procalcitonin and C-reactive protein as markers of infection in the newborn. Clin Chem Lab Med. 2011;49(2):227–231.
Kordek A., et al. Interleukin-6 as a predictor of neonatal infection severity. J Matern Fetal Neonatal Med. 2014;27(18):1875–1880.
Costa J.M., et al. PCR for detection of congenital infections. J Clin Microbiol. 2010;48(5):1752–1758.
Neu N., Duchon J., Zachariah P. TORCH infections. Clin Perinatol. 2015;42(1):77–103.
Lawn J.E., Blencowe H., et al. Global causes of neonatal death: a systematic analysis. Lancet. 2014;384(9933):447–455.
WHO. Congenital and neonatal infections: global overview. World Health Organization, 2022.
Saiman L., et al. Guidelines for management of neonatal infections. Pediatr Infect Dis J. 2010;29(12):113–120.
Dunlop A.L., et al. Prevention of perinatal infections through maternal care. Obstet Gynecol Surv. 2012;67(5):327–338.
Boppana S.B., Britt W.J. Congenital cytomegalovirus infection: clinical outcome. Clin Infect Dis. 1995;20(3):665–670.
Polin R.A., et al. Neonatal sepsis: diagnosis and management guidelines. Pediatrics. 2012;129(5):1006–1015.
Kimberlin D.W., et al. Antiviral therapy of neonatal herpes simplex virus infection. N Engl J Med. 1996;334:689–695.
Stagno S., et al. Maternal infection and congenital toxoplasmosis. N Engl J Med. 1988;318:271–274.
McCollum J., et al. Use of biomarkers for early detection of neonatal infections. J Infect. 2019;78(5):367–375.
Arora N., et al. Prevention and early detection of congenital infections: role of prenatal care. J Perinatol. 2017;37:1215–1222.
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