Articles
| Open Access |
https://doi.org/10.55640/
FEATURES OF THE ORAL IMMUNE STATUS IN VIRAL STOMATITIS BASED ON ORAL FLUID ANALYSIS
1.Turaeva Firuza Abdurashitovna,2.Juraeva Ferangiz Hakimovna , 1.Bukhara State Medical Institute 2.Osiyo International UniversityAbstract
Oral fluid is an informative biological substrate reflecting the state of mucosal immunity. This article reviews changes in the cytokine profile, levels of secretory IgA, innate antimicrobial factors, and virus-specific antibodies in patients with viral stomatitis (herpetic and HPV-associated) compared with healthy individuals. A critical analysis of current studies identified known patterns and outlined unresolved issues. Directions for future research are defined, including the role of interferon response and the impact of HPV co-infection.
Keywords
oral fluid; viral stomatitis; herpes simplex virus; human papillomavirus; cytokines; secretory IgA; β-defensins; lactoferrin; immunological parameters; diagnostics.
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