This literature review analyzes and synthesizes current data on the morphological and immunohistochemical features of the oral epithelium in HPV-associated stomatitis. While the role of the human papillomavirus (HPV) in oropharyngeal carcinogenesis is well-established, its significance in the development of benign and potentially malignant disorders of the oral mucosa, collectively referred to as "stomatitis," requires precise characterization. The review examines specific alterations in epithelial architecture and the expression patterns of key immunohistochemical markers, such as p16 and Ki-67, which are indicators of viral activity and disrupted cell proliferation. Based on the analysis of the literature, it is concluded that a combination of morphological and immunohistochemical methods is crucial for accurate diagnosis, assessment of progression potential, and developing management strategies for patients with HPV-associated oral mucosal lesions.

HPV, Human Papillomavirus, Stomatitis, Oral Mucosa, Morphology, Immunohistochemistry, p16, Ki-67, Diagnosis, Review.

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