This review synthesizes research on "Effectiveness of secondary preventive strategies in reducing recurrent myocardial infarction after coronary artery stenting in acute myocardial infarction patients" to address persistent morbidity and mortality despite revascularization advances. The review aimed to evaluate pharmacological efficacy, benchmark lifestyle interventions, assess adherence and barriers, compare antiplatelet therapy durations, and analyze multifactorial prevention approaches. A systematic analysis of randomized trials, meta-analyses, observational cohorts, and guidelines from Asia, Europe, and North America was conducted, focusing on clinical outcomes, adherence, and intervention impact. Pharmacological therapies, including statins and antiplatelets, significantly reduce recurrent events and mortality, though adherence and optimal dual antiplatelet therapy duration remain challenges. Lifestyle modification programs and cardiac rehabilitation improve event-free survival and risk profiles, yet suffer from variable adherence and underutilization.

rehabilitation, secondary prevention, stenting, recurrence, adherence, pharmacotherapy, lifestyle

Kanemitsu K. et al. The Impact of Lifestyle Intervention Programs on Long-Term Cardiac Event-Free Survival in Patients With Established Coronary Artery Disease // Cureus. 2024.

Stähli B.E., Landmesser U. Optimale medikamentöse Therapie bei Patienten nach akutem Koronarsyndrom // Deutsche Medizinische Wochenschrift. 2018.

Jaumdally R., Lip G., Varma C. Percutaneous coronary interventions for coronary artery disease: the long and short of optimizing medical therapy. // International Journal of Clinical Practice. 2005.

Lim S. et al. Risks of Recurrent Cardiovascular Events and Mortality in 1-Year Survivors of Acute Myocardial Infarction Implanted with Newer-Generation Drug-Eluting Stents. // Journal of Clinical Medicine. 2021.

Wood D.A. et al. EUROACTION: A European Society of Cardiology demonstration project in preventive cardiology. A cluster randomized controlled trial of a multidisciplinary preventive cardiology program for coronary patients, asymptomatic high-risk individuals, and their families. Summary of design, methodology, and outcomes // European Heart Journal Supplements. 2004.

Brinks J. et al. Lifestyle Modification in Secondary Prevention: Beyond Pharmacotherapy. // American Journal of Lifestyle Medicine. 2017.

Tea V. et al. Appropriate secondary prevention and clinical outcomes after acute myocardial infarction according to atherothrombotic risk stratification: The FAST-MI 2010 registry. // European Journal of Preventive Cardiology. 2019.

Long-term outcomes of the Coordinated Care Program in Patients after Myocardial Infarction (KOS-MI) // Kardiologia Polska. 2023.

Abrantes, A., et al. Secondary prevention in young patients after acute ST segment elevation myocardial infarction: missing the goals and suffering the penalties // European Journal of Preventive Cardiology. 2024.

Yudi M.B. et al. Prognostic Significance of Suboptimal Secondary Prevention Pharmacotherapy After Acute Coronary Syndromes // Internal Medicine Journal. 2021.

Khan M.R. et al. Evaluating the efficacy of statins, aspirin, and antihypertensive therapy in preventing recurrent cardiovascular events in post-myocardial infarction patients: a meta-analysis. 2024.

Lisspers, J., et al. Long-Term Effects of Lifestyle Behavior Change in Coronary Artery Disease: Effects on Recurrent Coronary Events After Percutaneous Coronary Intervention. // Health Psychology. 2005.

Michelsen H.Ö. et al. Effect of a lifestyle-focused web-based application on risk factor management in post-myocardial infarction patients: a randomized controlled trial (Preprint). 2020.

Degrauwe S. et al. Dual antiplatelet therapy for secondary prevention of coronary artery disease. 2017.

Roh J.W. et al. Clinical Impact of Single and Dual Antiplatelet Therapy Beyond 12 Months on Ischemic Risk in Patients With Acute Myocardial Infarction // Frontiers in Cardiovascular Medicine. 2021.

Xu J. Effectiveness of an AI-Based Secondary Prevention Management Model for Coronary Heart Disease on the Prognosis of Patients After Coronary Intervention for Acute Myocardial Infarction: A Randomized Controlled Trial (Preprint). 2023.