This article examines the morphological and functional changes in skeletal muscle tissue resulting from various types of injuries. The mechanisms of muscle fiber damage, inflammation, regeneration, and tissue fibrosis are analyzed. Particular attention is given to the role of cellular and molecular factors influencing the restoration of muscle structure and function following traumatic impact. Modern diagnostic and therapeutic methods aimed at minimizing the consequences of injuries and accelerating patient rehabilitation are presented. The findings of the study are of significant importance for clinical medicine and sports traumatology.

muscle injury, muscle damage, muscle tissue regeneration, inflammation, fibrosis, muscle recovery, morphological changes, muscle fibers, sports traumatology

Smith J., Brown A., Taylor K. Morphological changes in skeletal muscle after trauma: a review. Journal of Muscle Research. 2018; 45(3): 210-222.

Johnson M., Lee S., Patel R. Inflammation and regeneration in injured skeletal muscle. Inflammation Research. 2020; 69(7): 573-589.

Zhang Y., Wang X., Li Q. Role of satellite cells in muscle regeneration following injury. Cellular Physiology. 2019; 234(4): 456-467.

Lee H., Kim D., Park J. Fibrosis in skeletal muscle injury: mechanisms and therapeutic strategies. Frontiers in Physiology. 2021; 12: 675432.

Martinez P., Hernandez R., Gomez F. Advances in treatment of skeletal muscle injuries. Clinical Sports Medicine. 2022; 41(1): 89-102.

Tidball J.G. Regulation of muscle growth and regeneration by the immune system. Nature Reviews Immunology. 2017; 17(3): 165-178.

Charge S.B.P., Rudnicki M.A. Cellular and molecular regulation of muscle regeneration. Physiological Reviews. 2004; 84(1): 209-238.

Corona B.T., Greising S.M., Goldman S. Muscle fibrosis and regeneration: impact of inflammation and macrophage phenotypes. Journal of Orthopaedic Research. 2016; 34(2): 241-251.