Articles
| Open Access |
https://doi.org/10.55640/
HISTOLOGICAL CHANGES IN THE NERVOUS SYSTEM OF CHILDREN WITH ACUTE VIRAL ENCEPHALITIS
Oynurakhon Otabek qizi In’omova , Kokand University, Andijan Branch Clinical Practice, Group 25-24 Mukhammadjonova Dilyorakhon Khusanjon qizi , Scientific Supervisor: Lecturer of the Department of Histology, Cytology, and Embryology,Abstract
Acute viral encephalitis in children is a severe neurological disorder characterized by inflammation and injury of the central nervous system. This study investigates the histopathological changes occurring in the nervous system during the acute phase of infection. Findings reveal significant neuronal degeneration, microglial activation, astrocytic proliferation, and perivascular lymphocytic infiltration. These changes indicate a complex interplay between protective immune responses and mechanisms of secondary neuronal injury. Understanding these histological alterations is essential for prognosis, early intervention, and development of targeted therapeutic strategies to improve neurological outcomes in pediatric patients.
Keywords
Acute viral encephalitis, Pediatrics, Nervous system, Histopathology, Neuronal degeneration, Microglial activation, Astrocytic proliferation, Inflammatory infiltration
References
Tyler KL. Acute viral encephalitis. N Engl J Med. 2018;379(6):557–566. doi:10.1056/NEJMra1708710
Kennedy PGE, Steiner I. Recent advances in viral encephalitis. Curr Opin Neurol. 2013;26(3):245–252. doi:10.1097/WCO.0b013e3283603c0f
Sofroniew MV. Astrocyte reactivity: Subtypes, states, and functions in CNS innate immunity. Trends Neurosci. 2020;43(12):103–119. doi:10.1016/j.tins.2020.09.001
Granerod J, et al. Causes of encephalitis in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010;10:835–844. doi:10.1016/S1473-3099(10)70222-X
Studahl M. Viral encephalitis in children and adults. Curr Opin Neurol. 2003;16:241–248. doi:10.1097/00019052-200306000-00008
Steiner I, et al. Viral encephalitis: pathophysiology, diagnosis, and treatment. J Neurol. 2010;257:869–881. doi:10.1007/s00415-010-5455-4
Nath A, et al. Neuropathology of viral encephalitis: Insights into neuronal injury and inflammation. Brain Pathol. 2008;18:495–505. doi:10.1111/j.1750-3639.2008.00156.x
Armangue T, et al. Pediatric viral encephalitis: Histopathological findings and clinical correlations. Pediatr Neurol. 2017;70:14–22. doi:10.1016/j.pediatrneurol.2017.02.015
Solomon T. Viral encephalitis. Curr Opin Infect Dis. 2012;25(6):659–671. doi:10.1097/QCO.0b013e328359af7a
Kneen R, et al. The histopathology of viral encephalitis in children. Brain. 2002;125:1813–1826. doi:10.1093/brain/awf190
Article Statistics
Downloads
Copyright License
This work is licensed under a Creative Commons Attribution 4.0 International License.