Articles | Open Access | https://doi.org/10.55640/

CERVICAL PATHOLOGY AND VAGINAL MICROBIOME IN INTRAUTERINE DEVICE USERS: RISKS AND OBSERVATIONS

Atakhodjaeva F.A., Tashbaeva U.I. , Associate Professor, Tashkent State Medical University, Tashkent, Uzbekistan, Master’s degree, Tashkent State Medical University

Abstract

 This article studies the correlation between the prolonged use of intrauterine contraceptive devices (IUDs) and the development of cervical pathology. A comparative analysis of clinical, cytological, colposcopic, and microbiological data was conducted in women with and without IUDs. A higher incidence of inflammatory changes and low-grade cervical intraepithelial neoplasia (CIN 1) was revealed among IUD users.

Keywords

Intrauterine device, cervix, dysplasia, CIN 1, inflammation, HPV, colposcopy, cytology.

References

International Agency for Research on Cancer. Cervical Cancer. Global Cancer Observatory. 2022. https://www.iarc.who.int/cancer-type/cervical-cancer

Bosch FX, Lorincz A, Muñoz N, Meijer CJ, Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol. 2002;55(4):244-265. doi:10.1136/jcp.55.4.244

Schiffman M, Wentzensen N. From human papillomavirus to cervical cancer. Obstet Gynecol. 2010;116(1):177–185. doi:10.1097/AOG.0b013e3181eeb2a9

United Nations, Department of Economic and Social Affairs, Population Division. World Contraceptive Use 2023. https://www.un.org/development/desa/pd/data/world-contraceptive-use

Skorstengaard M, Lynge E, Napolitano G, et al. Risk of precancerous cervical lesions in women using a hormone-containing intrauterine device and other contraceptives: a register-based cohort study from Denmark. Hum Reprod. 2021;36(7):1796–1807. doi:10.1093/humrep/deab104

Kim K, Park H, Kim H, et al. Association of intrauterine device use with risk of cervical intraepithelial neoplasia and HPV infection: a nationwide cohort study. Sci Rep. 2021;11:21599. doi:10.1038/s41598-021-01086-6

Castellsagué X, Díaz M, Vaccarella S, et al. Intrauterine device use, cervical infection with human papillomavirus, and risk of cervical cancer: a pooled analysis of 26 epidemiological studies. Lancet Oncol. 2011;12(11):1023–1031. doi:10.1016/S1470-2045(11)70223-6

Solomon D, Nayar R. The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes. 3rd ed. Springer; 2015.

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CERVICAL PATHOLOGY AND VAGINAL MICROBIOME IN INTRAUTERINE DEVICE USERS: RISKS AND OBSERVATIONS. (2025). International Journal of Medical Sciences, 5(10), 465-473. https://doi.org/10.55640/