In this experimental study, histostructural changes in the liver tissue were examined using a rat model fed with a high-fat diet. The observed histostructural alterations correspond to the main stages of non-alcoholic fatty liver disease (NAFLD), including steatosis (fat accumulation in the hepatic parenchyma), inflammation, and fibrosis, each demonstrating distinct developmental features. These findings provide an opportunity to assess the mechanisms of NAFLD progression under experimental conditions and reveal the clinical-morphological correlations of the disease.

NAFLD, high-fat diet, liver, experimental model, histostructure, steatosis, fibrosis, ballooning degeneration.

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