Hypertensive disorders during pregnancy are a major global health concern. According to the World Health Organization (WHO), the prevalence of arterial hypertension among the middle-aged population was estimated to be 20-30% in 2008. By 2021, the prevalence of hypertension among adults had increased to 25-35%, and it is projected to rise by an additional 5-10% by 2023. Notably, the prevalence of arterial hypertension during pregnancy is significantly higher, ranging from 35-45%.

Pregnancy with chronic arterial hypertension poses significant risks, including premature delivery, increased perinatal morbidity and mortality, and maternal complications. Pre-eclampsia and eclampsia, in particular, are severe complications of chronic arterial hypertension that can increase the risk of maternal death by 30-40%.

Despite the availability of standardized antihypertensive therapy guidelines for pregnant women, the early detection and effective management of chronic arterial hypertension during pregnancy remain challenging. This is crucial for preventing complications, reducing maternal and fetal mortality, and ensuring a safe and healthy pregnancy. Therefore, further research is needed to investigate the effects of antihypertensive drugs on pregnancy outcomes in women with chronic arterial hypertension.

Arterial hypertension, Pregnancy, Pre-eclampsia, Eclampsia, Antihypertensive therapy.

Antihypertensive drug therapy for mild to moderate hypertension

during pregnancy. Edgardo Abalos, LeliaDuley, D Wilhelm Steyn, Centro Rosarino de EstudiosPerinatales (CREP), Rosario, Argentina. 2Nottingham Clinical Trials Unit, Nottingham Health SciencePartners, Nottingham, UK. 3Obstetrics &Gynaecology, University of Stellenbosch, Tygerberg, South Africa 2014

Antihypertensive drug therapy for mild to moderate hypertension

during pregnancy (Review). Abalos E, Duley L, Steyn DW, Gialdini C.

Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database of Systematic Reviews 2018, Issue 10. Art. No.: CD002252. DOI: 10.1002/14651858.CD002252.pub4.

Antihypertensive medication use during pregnancy in a real-world cohort of patients diagnosed with a hypertensive disorder of pregnancy. Julian E. Garcia1 Ian R. Mulrenin1 1 Matthew S. Loop1,2 Melissa A. Daubert3 Rachel Urruti

Cardiovascular mortality in women in their forties after hypertensive disorders of pregnancy in the Netherlands: a national cohort study Sophie M Welters, Marjon de Boer, Pim W Teunissen, Wietske Hermes, Anita C J Ravelli, Ben W Mol, Christianne J M de Groot

Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy:an open-label, randomised controlled trial Thomas Easterling, ShuchitaMundle, Hillary Bracken, Seema Parvekar, SulabhaMool, Laura A Magee, Peter von Dadelszen, Tara Shochet, Beverly Winikoff

Пероральные антигипертензивные схемы (нифедипинретард, лабеталол и метилдопа) для лечения тяжелой гипертензии во время беременности: открытое рандомизированное контролируемое исследованиеТомас Истерлинг ,ШучитаМундл , Хиллари Брекен , Сима Парвекар , СулабхаМул,ЛаураМаги,Петер фон Дадельзен,ТараШошет,БеверлиВиникофф

Prevalence of Hypertension Among Pregnant Women When Using the 2017American College of Cardiology/American Heart Association Blood PressureGuidelines and Association With Maternal and Fetal Outcomes. Natalie A. Bello, MD, MPH; Hui Zhou, PhD; T. Craig Cheetham, PharmD, MS; Eliza Miller, MD, MS; DariosGetahun, MD, PhD, MPH;

Michael J. Fassett, MD; Kristi Reynolds, PhD, MPH

Safety of Antihypertensive Medications in Pregnancy: Living WithUncertainty Line Malha, MD, MS; Phyllis August, MD, MPH

Treatment for Mild Chronic Hypertension during Pregnancy. A.T. Tita, J.M. Szychowski, K. Boggess, L. Dugoff, B. Sibai, K. Lawrence, B.L. Hughes, J. Bell, K. Aagaard, R.K. Edwards, K. Gibson, D.M. Haas, L. Plante, T. Metz, B. Casey, S. Esplin, S. Longo, M. Hoffman, G.R. Saade, K.K. Hoppe, J. Foroutan, M. Tuuli, M.Y. Owens, H.N. Simhan, H. Frey, T. Rosen, A. Palatnik, S. Baker, P. August, U.M. Reddy, W. Kinzler, E. Su, I. Krishna, N. Nguyen, M.E. Norton, D. Skupski, Y.Y. ElSayed, D. Ogunyemi, Z.S. Galis, L. Harper, N. Ambalavanan, N.L. Geller, S. Oparil, G.R. Cutter, and W.W. Andrews, for the Chronic Hypertension and Pregnancy (CHAP) Trial Consortium*

Treatment for Mild Chronic Hypertension during PregnancyPublished in final edited form as:NEngl J Med. 2022 May 12; 386(19): 1781–1792. doi:10.1056/NEJMoa2201295.

Which antihypertensive treatment is better for mild to moderatehypertension in pregnancy? Danielle Ashworth, Cheryl Battersby, Marcus Green, Pollyanna Hardy, Richard J McManus, Catherine Cluver, Lucy C Chappell1Danielle Ashworth, Cheryl Battersby, Marcus Green, Pollyanna Hardy, Richard J McManus, Catherine Cluver, Lucy C Chappel