Articles
| Open Access |
https://doi.org/10.55640/
RECURRENT EPISODES OF NONHISTAMINERGIC ANGIOEDEMA IN A POSTMENOPAUSAL WOMAN: A CLINICAL CASE
Nosirova M.P. , Republican Specialized Scientific and Practical Medical Center of Allergology and Clinical Immunology Assistant Professor, Department of Allergology, Clinical Immunology, and Nursing Tashkent State Medical UniversityAbstract
Nonhistaminergic angioedema (NH-AO) is a rare, heterogeneous condition characterized by recurrent episodes of tissue swelling due to a bradykinin-mediated or other nonmastocyte-mediated mechanism. Diagnosis of NH-AO remains challenging, particularly when the disease presents in adults without a family history or drug triggers. Hormonal changes during menopause may affect the kallikrein-kinin system and contribute to the clinical presentation; however, case reports are limited.
We present a 67-year-old postmenopausal woman with recurrent episodes of angioedema unresponsive to antihistamines and glucocorticosteroids. The patient had normal C1 inhibitor levels and functional activity, and no evidence of acquired or drug-induced causes. The clinical presentation was consistent with idiopathic nonhistaminergic angioedema. This case highlights the need to consider nonhistaminergic angioedema in middle-aged and older women with angioedema without urticaria. Possible hormonal mechanisms influencing vascular permeability and bradykinin metabolism require further study.
Keywords
nonhistaminergic angioedema; bradykinin; menopause; idiopathic angioedema; C1 inhibitor.
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