This study investigates the pathomorphological features of liver neoplasms and the effects of high-protein dietary intake on hepatocyte morphology. Using an experimental model with Wistar rats, the research assessed hepatocyte size, nuclear-to-cytoplasm ratio, mitotic activity, and tumor differentiation under normal, high-protein, and neoplasm-induced conditions. Results demonstrated that a high-protein diet induced hepatocyte hypertrophy and increased proliferative activity under normal conditions, whereas liver neoplasms caused pronounced structural alterations, including nuclear pleomorphism and necrotic areas. High-protein intake in neoplasm-bearing rats slightly affected hepatocyte size but did not prevent tumor-induced changes. These findings highlight the complex interaction between nutrition and liver pathology, providing insights for preclinical research, dietary strategies, and therapeutic approaches in hepatology.

liver neoplasms, pathomorphology, hepatocytes, high-protein diet, histology, morphometry, Wistar rats

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