Cardioembolic stroke (CES) is a growing part of ischemic strokes and may have increased several-fold in recent decades. However, the study suggests several potential strategies to halt the expected increase in cardioembolic stroke. Although the causes of one-third of strokes are unknown, it is increasingly accepted that most of these cryptogenic strokes are due to embolic causes rather than cerebrovascular disease, which has recently led to the development of embolic stroke of unknown origin as a specific target.

Patients with cardioembolic stroke due to atrial fibrillation are difficult to treat in the acute phase of the disease. By identifying blood biomarkers that cause ischemic stroke, it is possible to find the etiological cause of cardioembolic stroke and thereby provide patients with correct diagnosis and treatment guidelines. Scientists have found that there is a direct correlation between changes in the amount of natriuretic peptides and heart rhythm. It has been found that the amount of LP-PLA2 in the blood indicates the risk of ischemic stroke among patients with atherosclerosis of large vessels.

Cardioembolic stroke due to atrial fibrillation shows a connection between the rhythms that cause large focal damage to brain cells. In the presence of an inflammatory process and the interaction of amino acids, the p38MAPK gene is activated and ischemic brain damage occurs. The results obtained in this research activity were found to have practical significance for the diagnosis of CES. The introduction of neuroimaging methods into clinical practice makes it possible to detect acute circulatory disorders at an early stage, to establish etiopathogenetic relationships between heart and brain pathology, and, as a result, to choose the right path for the treatment of patients. When suspected of cardiocerebral infarction, the diagnosis can be confirmed using CT, CT angiogram, CT perfusion, MRI, MRA (magnetic resonance angiography), MRS (magnetic resonance spectroscopy), and ECG methods of examination of the brain.

atrial fibrillation, cardioembolic stroke, sinus rhythm

Khadzhieva DT, Nurova ZH. Optimization of treatment of early neurological complications in cardioembolic stroke // Salon bio and construction. Strasbourg, 2021, – P. 38-39.

Mukhamadieva N. B. Tuksanova Z. I. Influence of the course of myocardial infarction on the development of depressive disorders. "Young Scientist" scientific joumal. №l 1(91).June 2018, 681-682 p.

Diagnosis and treatment of atrial fibrillation. Recommendations of the RKO, VNOA and ASSH. Moscow 2012.

Garcia D, Libby E, Crowther MA. The new oral anticoagulants. Blood, 2020, 115: 15-20.

Nurova Z. H., Z. I. Tuksanova. Optimization of treatment of early neurological complications in cardioembolic stroke. A new day in medicine. -. 2020. - No. 4. - pp. 615-616.

Khodzhieva D. T„ Tukhtaev I. T. Evaluation of the effectiveness of acupuncture in the complex treatment of neurological disorders in ischemic stroke// Certificate of official registration of the program for electronic computers. MGency for Intellectual Property of the Republic of Uzbekistan. - 2020. - No. DGU 09652.

Khodzhieva D. T., Dzhunaidova A. H. Rehabilitation of patients with acute disorders of cerebral circulation and improvement//Joumal of Clinical Psychology and Psychiatry. - 2020. - No. 1. - pp. 13-19.

Hodjieva D. T., Khaydarov D. K. Violation of cerebral circulation in occlusii lesions of the carotid arteries// A new day in medicine - 2019. - P. 33 -37.

Hodjieva D.T., Khaydarov D. K., Axrorova B. S., Rakhmatov, D. I., Akhmatova N. R. research of neurological patients/Publisher the Durdona. Bukhara - 2019.

Khodjieva D.T., Nurova Z.H., Khaydarov N.K., Khaydarova D.K. Optimization of the diagnosis and treatment of early neurological complications in cardio embolicstroke// European Journal of Molecular & Clinical Medicine. 2021,- P.5788-5792.