The article presents the main characteristics of ureaplasmas, discusses methods of diagnosis, treatment and prevention of ureaplasma infection. It is noted that it is necessary to identify both specific and non-specific pathogens in a timely manner in order to prescribe optimal antibacterial therapy. Special attention is paid to the macrolide antibiotic josamycin, which is recommended by leading urologists as a first–line drug for the treatment of ureaplasma and mycoplasma infections and, if prescribed in a timely manner, can achieve a complete cure in 97.5% of cases. In recent decades, the frequency of ureaplasma and mycoplasma infections has increased significantly, which most often affects the genitourinary system in women. However, experts still doubt whether ureaplasmosis can be considered a separate disease, since its causative agent is found in the vagina in healthy women in 60%, and in newborn girls in 30% of cases [1, 2]. 

ureaplasma, sensitivity to antibiotics josamycin, adhesins, urease, PCR.

Bonkat G, Pickard R, Bartoletti R, T. Cai, F. Bruyère, S.E. Geerlings, B. Köves, F. Wagenlehner, Guidelines Associates: A. Pilatz, B. Pradere, R. Veeratterapillay.EAU Guidelines on Urological Infections. Edition presented at the EAU AnnualCongress Copenhagen 2018. ISBN 2018 2. Chen YH, Ko WC, Hsueh PR. The role of fluoroquinolones in the anagement of urinary tract infections in areas with high rates of fluoroquinolone-resistanturopathogens. Eur J Clin Microbiol Infect Dis. 2012;31(8):1699-1704 DOI:10.1007/s100 96-011-1457-x 3. Foxman B. 2014. Urinary tract infection syndromes: occurrence, recur rence,bacteriology, risk factors, and disease burden. Infect Dis Clin North Am 28:1–2 4. Mamatmusaeva, F., Tuychiev, L., Nuruzova, Z., Yodgorova, N., & Orinbaeva, Z.(2020). Optimizing the treatment of biliary disease in children with viralhepatitis. International Journal of Pharmaceutical Re search, 12(4), 536-541. 5. Tratselas A, Iosifi dis E, Ioannidou M, et al. Outcome of urinary tract infectonscaused by extended spectrum ß-lactamase-producing nterobacteriaceae in children. Pediatr Infect Dis J. 2011;30:707–709 6. Gomberg M. A.Management of patients with mycoplasma infection / M. A. Gomberg // Gynaecology. – 2009. – T. 11, No. 4. – pp. 48-51. 2. Dyudyun A.D. Complex interference therapy and medical examination of patients with recurrent urinary infections (chlamydia, trichomoniasis, ureaplasmosis, candidiasis, bacterial vaginosis) : abstract of the dissertation of the Doctor of Medical Sciences: 14.01.20 / Dyudyun Anatoly Dmitrovich; National Medical University im. O. O. Bogomolts. – K., 2003. – 34 p. 3. Mavrov I. I. Sexual diseases: textbook. the manual / - M., 2002. – 735 p. 4. Molochkov V. A. Sexually transmitted infections / V. A. Molochkov, O. L. Ivanov, V. V. Chebotareva. - M.: Medicine, 2006. – 632 p. 5. Kubanova A. A., Rakhmatulina M. R. Urogenital infectious diseases caused by genital mycoplasmas. Clinical recommendations // Vestn. Derm. and venereology. - 2009. – No. 3. – pp. 78-82. 6. Kuznetsechenkova T. V. Urogenital mycoplasma infection: features of epidemiology, clinic and secretory immunity in women of various social groups: dis. ... Candidate of Sciences. honey. Sciences: 01/14/10 / Kuznetsenkova Tatiana Vladimirovna; Federal State Institution "Ural Scientific Research Institute of Dermatology and Immunopathology". - Esa-Edinburgh, 2011. – 150 p. 7. Nemchenko O. I. Urogenital mycoplasmosis (review of literature) / O. I. Nemchenko, E. V. Uvarova // Consilium Medicum. – 2007. – No. 1. – pp. 45-51