The aim of the study: early diagnosis of bone demineralization in patients with exocrine insufficiency and vitamin D deficiency. Material and methods: The research was conducted in the Department of gastroenterology at the multidisciplinary clinic of TMA. 92 patients with CP (29 men and 63 women) aged 31-83 years (mean age 58.40±1.29 years) and 15 practically healthy individuals (mean age 39.73±4.92 years) were examined.

Studies have shown impaired extracretory insufficiency in patients with CP, manifested by a decrease in elastase activity from 208.27+10.83 to 176.69+7.12 in biliary, to 169.75+25.88 in idiopathic, and to 125+5.44 in mixed forms of CP. It should be noted that the patients we had examined gastric digestive insufficiency: with biliary CP, it was detected in 19.18%, with idiopathic CP – in 25%, with mixed form – in 18.18% of the examined patients. However, pancreatic insufficiency was more often detected in the examined patients: 69.86% with CP of the biliary tract and 81.81% with mixed form. At the same time, bile insufficiency was more characteristic of the idiopathic form of CP, being detected in 75% of patients, whereas with biliary and mixed genesis it was detected in 50.68 and 55% of the examined, respectively. This is confirmed by the presence of bile acid salts in the feces of 75% of patients with idiopathic form of the disease, in 31.51 and 45.45% of those examined with biliary and mixed forms of CP. Digestive insufficiency in the small intestine was detected with a lower frequency: in 21.92% of patients with biliary form and in 36.36% with mixed forms of the disease. Similar dynamics were typical for dyspepsia in the colon, which was observed in 10.96% and 18.18% of the examined patients with biliary and mixed forms of chronic pancreatitis.

chronic pancreatitis, vitamin D deficiency.

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