The main objective of this article is to identify the specific pathomorphological changes characteristic of lymphocytic leukemia in young children. From a pathomorphological perspective, childhood lymphocytic leukemia is manifested by focal leukemic infiltration in the bone marrow and almost all lymphoid organs at the early stages of the disease. Depending on whether the lymphocytic leukemia develops from T or B lymphocytes, leukemic infiltration appears in specific areas of the lymphoid organs. In lymphocytic leukemia, pathomorphological changes initially occur in the stromal-vascular structures of the organs and subsequently spread to the parenchyma.

The aim of this study was to examine the pathomorphological changes associated with childhood lymphocytic leukemia. In children, lymphocytic leukemia is manifested by the appearance of focal leukemic infiltrates in the bone marrow and in all lymphoid organs. Depending on whether the leukemia originates from T or B lymphocytes, the leukemic infiltrates are localized in the corresponding T- or B-cell zones. Initially, leukemic cells appear in the stroma of the organs and subsequently infiltrate the parenchyma.

children, leukemia, lymphocytic leukemia, bone marrow, thymus, spleen, lymph node, liver, leukemic infiltration

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