Articles
| Open Access |
https://doi.org/10.55640/
TAKOTSUBO CARDIOMYOPATHY: PATHOPHYSIOLOGY, CLINICAL FEATURES, AND CURRENT PERSPECTIVES
Lutfullayev Oltin Oybek ugli , Asia International University,Bukhara,UzbekistanAbstract
Takotsubo cardiomyopathy (TTC), also known as stress-induced cardiomyopathy or “broken heart syndrome,” is a transient left ventricular dysfunction that mimics acute coronary syndrome (ACS) but occurs without obstructive coronary artery disease. This article explores the pathophysiology, clinical features, diagnostic principles, and neurohormonal mechanisms underlying TTC, emphasizing the roles of catecholamine toxicity, microvascular dysfunction, estrogen deficiency, and the neuro–cardiac axis.
Keywords
Takotsubo cardiomyopathy; stress-induced cardiomyopathy; catecholamines; microvascular dysfunction; apical ballooning; neuro–cardiac axis
References
Templin C, et al. Clinical Features and Outcomes of Takotsubo Cardiomyopathy. NEJM.
Ghadri JR, et al. International Expert Consensus Document on Takotsubo Syndrome. Eur Heart J.
Lyon AR, et al. Current Knowledge on Takotsubo Syndrome. Heart Failure Clinics.
Nef HM, et al. Mechanisms of Stress-Induced Cardiomyopathy. Nat Rev Cardiol.
Wittstein IS, et al. Neurohumoral Features of Myocardial Stunning Due to Emotional Stress. NEJM.
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This work is licensed under a Creative Commons Attribution 4.0 International License.