Last​ in years sepsis severe arterial hypotension , cardiogenic and​​ distributive shock in cases vasopressors (noradrenaline, vasopressin , dopamine , phenylephrine) and others ) life save stay for first in line is being used . Long term and high in doses vasopressor infusion endothelial in cells , smooth muscle on the floor and vein of the wall in the structure reversible and irreversible morphological to changes take arrival This is defined . in the thesis vasopressors vein to the wall impact mechanisms , histological and ultrastructure changes , as well as this of changes clinical consequences analysis will be done .

vasopressors , noradrenaline, arterial hypotension , endothelial dysfunction , vein wall remodeling , smooth muscle cells apoptosis , intensive therapy , sepsis shock​

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