Pregnancy is accompanied by profound physiological changes in the maternal organism, including significant adaptations of renal function. Pregnant rats are widely used as an experimental model to study renal physiology due to similarities in fundamental regulatory mechanisms with humans. This article analyzes anatomical and functional changes in the kidneys of pregnant rats, renal hemodynamics, glomerular filtration rate, tubular reabsorption, and hormonal regulation of water–electrolyte balance. Understanding these mechanisms is essential for modeling pregnancy-related renal disorders and evaluating pharmacological interventions.

pregnancy, kidneys, rats, glomerular filtration rate, renal physiology, hormonal regulation.

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