This scientific article provides an in-depth analysis of the complex relationship between depression and menstrual disorders based on a psychoneuroendocrine approach. The interaction of mood, the central nervous system, and the endocrine system is of great importance in women's health. Studies show that depressive disorders can be an important etiological factor in the development of conditions such as delayed menstrual cycles, amenorrhea, dysmenorrhea, and premenstrual syndrome. The article discusses the effects of the hypothalamic-pituitary-ovarian axis, stress hormones, serotonin, and cortisol on the female reproductive system based on scientific sources [3, 5]. Literature analysis and a theoretical approach were used as the research methodology. The results indicate a strong bidirectional relationship between depression and menstrual disorders.

depression, menstrual cycle, psychoneuroendocrine system, stress, hormones, women's health, serotonin, cortisol

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