This article examines exposomes as a new paradigm of preventive medicine, focused on a comprehensive assessment of the combined impacts of environmental factors, lifestyle, socioeconomic conditions, and biological processes on human health throughout life. It is demonstrated that the traditional approach, based on the analysis of individual risk factors, does not fully reflect the multifactorial nature of disease development, particularly non-communicable diseases. This review discusses the theoretical foundations of the exposome concept, its structure and main components, as well as modern methods for studying exposure effects. Particular attention is paid to the potential of the exposome approach for the prevention of chronic and infectious diseases, the development of public health, and the development of effective preventive programs. A separate section is devoted to the relevance of exposomes for the healthcare system of Uzbekistan, taking into account the climatic, environmental, and social characteristics of the region. It is concluded that exposomes holds great promise as a tool for modernizing preventive medicine and improving public health.

Exposomes, preventive medicine, public health, exposure, risk factors, noncommunicable diseases, environment, social determinants, exposome.

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